CHEBI:27760

Three steps

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• 2-oxoglutaramateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by CTH, AGXT2, KYAT1cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by CTH, AGXT2, FAHD1cytosol

• CHEBI:16857Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of (R)-3-hydroxybutanoate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 7 morecytosol, extracellular spaceOne of 4 routes

• 3-hydroxypyruvateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by CTH, AGXT2, AGXTcytosol

• L-isoleucineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 3 routes

• CHEBI:17203Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 3 routes

• aceneuramateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by CTH, AGXT2, NPLcytosol

• pyridoxalReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxal-5'-phosphate phosphohydrolase

  Catalysed by CTH, SCLY, KLHL23, PHOSPHO2 and 2 morecytosol

• 5'-deoxyadenosineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CTH, AGXT2, TYW1B, TYW1cytosol

• AH2Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CTH, SCLY, MOCOScytosol

• L-cysteineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 11 routes

• indole-3-pyruvateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• Ala-tRNA(Ala)Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by CTH, SCLY, AARS1cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• CHEBI:17895Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• CHEBI:18019Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)

  Catalysed by CTH, SDS, SDSL, SLC1A5cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• dTDPReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. pyruvate kinase (dTDP)

  Catalysed by CTH, AGXT2, PKM, PKLRcytosol

• CHEBI:18095Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Transport of Hydroxy-Proline

  Catalysed by CTH, SCLY, SLC1A4cytosol, extracellular space

• seleniteReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. hydrogen selenide:NADP+ oxidoreductase

  Catalysed by CTH, SCLY, TXNRD1, TXNRD3 and 1 morecytosol

• 1,4-dithiothreitolReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. selenocysteine lyase (dithiothreitol)
  3. Vitamin K:oxidized-dithiothreitol oxidoreductase

  Catalysed by CTH, SCLY, VKORC1cytosolOne of 2 routes

• gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
  3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

  Catalysed by CTH, AADAT, GCLCcytosol

• 2-aminoisobutanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by CTH, SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CTH, SCLY, AGXT2cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by CTH, AGXT2cytosolOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by CTH, AGXT2cytosolOne of 2 routes

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. L-Serine hydro-lyase (adding homocysteine)
  2. Methionine Synthase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by CBS, SHMT1cytosol, nucleusOne of 5 routes

• 2-oxopentanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by CTH, AGXT2cytosol

• pyridoxine 5'-phosphateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CTH, SCLYcytosolOne of 3 routes

• a dicarboxylateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by CTH, AADAT, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• chlorine(.)Reach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC6A14cytosol, extracellular spaceOne of 2 routes

• glycolateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by CTH, AGXT2, GRHPRcytosol

• L-aspartateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by CTH, SCLY, AGXT2cytosol

• acetateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes

• oxalateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by CTH, AGXT2, HAO1cytosol

• formic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes

• propionic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and propanoate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 7 routes

• butyric acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and butyrate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. L-Serine:pyruvate aminotransferase

  Catalysed by CTH, AGXT2, AGXTcytosolOne of 2 routes

• glutarateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by CTH, AADAT, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by CTH, AGXT2cytosol

• 2-oxohexanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by CTH, AGXT2cytosol

• D-cysteineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by CTH, SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. D-serine = pyruvate + NH4(+)

  Catalysed by CTH, AGXT2, SRRcytosolOne of 7 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• (R)-lactic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by CTH, AGXT2, LDHDcytosol

• (S)-lactic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and L-lactate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 8 morecytosol, extracellular spaceOne of 7 routes