biocytin

Three steps

• CHEBI:16856Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by BTD, SLC7A6, GSSmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by BTD, SLC7A6, DAOmitochondrial matrix, extracellular space, cytosol, peroxisome

• oxalic acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by BTD, SLC6A14, SLC26A6mitochondrial matrix, extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by BTD, SLC7A5, SLC7A6, OATmitochondrial matrix, extracellular space, cytosol

• anilineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by BTD, NAT2, NAT1mitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by BTDmitochondrial matrix, cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by BTD, SLC7A6, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by BTD, SLC7A6, PRODH2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by BTD, SLC3A2, SLC7A5, SLC7A6mitochondrial matrix, extracellular space, cytosol

• AH2Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by BTD, SLC7A6, MOCOSmitochondrial matrix, extracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by BTD, SLC7A6, ALAS1, ALAS2 and 1 moremitochondrial matrix, extracellular space, cytosol

• indole-3-pyruvateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by BTD, SLC7A6, IL4I1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by BTD, HADHA, ACADVL, HADHBmitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by BTD, SLC7A6, AARS1mitochondrial matrix, extracellular space, cytosol

• glycine betaineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by BTD, SLC6A14, SLC6A12mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of histidine and lysine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by BTD, SLC7A5, SLC7A6, HALmitochondrial matrix, extracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by BTD, SLC7A6, TPH1, TPH2mitochondrial matrix, extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of leucine and lysine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by BTD, SLC7A6, BCAT2mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of arginine and lysine (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by BTD, SLC3A2, SLC7A5, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by BTD, SLC7A6, GOT2, TATmitochondrial matrix, extracellular space, cytosolOne of 5 routes

• CHEBI:18095Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by BTD, SLC7A6, SLC1A4mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• CHEBI:18183Reach from here →
  1. biocytin + H2O = biotin + L-lysine
  2. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  3. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]

  Catalysed by BTD, GGACTcytosolOne of 2 routes

• N-carbamoyl-beta-alanineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by BTD, SLC6A14mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by BTD, SLC7A6, GARTmitochondrial matrix, extracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by BTD, SLC7A6, DDCmitochondrial matrix, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by BTD, SLC7A6, PFASmitochondrial matrix, extracellular space, cytosol

• ophthalmateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by BTD, SLC7A6, GSSmitochondrial matrix, extracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by BTD, SLC7A6, SLC7A8mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by BTD, SLC7A6, SLC7A10mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. biocytin + H2O = biotin + L-lysine
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by BTD, SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 6 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by BTD, SLC7A6, AGXT2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by BTD, SLC7A6, SHMT1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by BTD, SLC7A6, CARS2mitochondrial matrix, extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by BTD, HADHA, ACAA2, HADHBmitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by BTD, HADHA, ACADVL, HADHBmitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by BTD, HADHA, ACADVL, HADHBmitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by BTD, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by BTD, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by BTD, SLC7A6, GLYAT, GLYATL2 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• hypochlorous acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by BTD, SLC6A14, LPOmitochondrial matrix, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by BTD, SLC6A14, SLC12A2, SLC12A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by BTD, SLC7A6, GLYATmitochondrial matrix, extracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by BTD, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by BTD, SLC7A6, TPH1, TPH2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by BTD, SLC7A6mitochondrial matrix, extracellular space, cytosol

• CHEBI:28701Reach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by BTD, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of alanine and lysine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by BTD, SLC7A6, SCLYmitochondrial matrix, extracellular space, cytosol