thiocyanate

Three steps

• a dicarboxylateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• a thiolReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by MPST, TST, SUMF1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC26A6mitochondrial matrix, cytosol, extracellular space

• D-aspartateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• oxalateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC26A2 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• citric acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by MPST, TST, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 5 routes

• butyric acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate:cyanide sulfurtranserase
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by MPST, TST, SLC25A10mitochondrial matrix, cytosolOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by MPST, TST, AGXTmitochondrial matrix, cytosolOne of 2 routes

• isocitric acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by MPST, TST, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• (2R,3R)-tartrateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by MPST, TST, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• 3-oxopropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosol

• methylarsonateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GSTO1 and 1 moremitochondrial matrix

• D-serineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by MPST, TST, SRRmitochondrial matrix, cytosol

• glyoxylateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by MPST, TST, SLC25A10, CLYBLmitochondrial matrix, cytosol

• (R)-lactic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by MPST, TST, LDHDmitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by MPST, TST, LDHB, LDHAL6Bmitochondrial matrix, cytosolOne of 5 routes

• 2-iminopropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by MPST, TST, RIDAmitochondrial matrix, cytosol

• phosphoenolpyruvic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. pyruvate kinase (dTDP)

  Catalysed by MPST, TST, PKM, PKLRmitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by MPST, TST, NPLmitochondrial matrix, cytosol

• a 3-acylpyruvateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by MPST, TST, FAHD1mitochondrial matrix, cytosol

• (S)-malyl-CoAReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by MPST, TST, SLC25A10, SUCLG1 and 1 moremitochondrial matrix, cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by MPST, TST, SLC25A10, ASLmitochondrial matrix, cytosolOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by MPST, TST, SLC25A10, ADSL and 1 moremitochondrial matrix, cytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosol

• L-methionineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by MPST, TST, TYW1B, TYW1mitochondrial matrix, cytosol

• N-sulfo-D-glucosamineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by MPST, TST, SGSHmitochondrial matrix, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by MPST, TST, STSmitochondrial matrix, cytosol

• glutathioneReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate:cyanide sulfurtranserase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by MPST, TST, TSTD1mitochondrial matrixOne of 9 routes

• L-alanineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosolOne of 18 routes

• adenosine 5'-phosphosulfateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. ATP:sulfate adenylyltransferase

  Catalysed by MPST, TST, PAPSS1, PAPSS2mitochondrial matrix, cytosolOne of 4 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by MPST, TST, SLC25A10, ADSLmitochondrial matrix, cytosolOne of 2 routes

• (3S)-citramalyl-CoAReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by MPST, TST, CLYBLmitochondrial matrix, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosol

• estrone 3-sulfateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by MPST, TST, STSmitochondrial matrix, cytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by MPST, TST, HOGA1mitochondrial matrix, cytosol

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by MPST, TST, SLC4A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• ubiquinol-10Reach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate:cyanide sulfurtranserase
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by MPST, TST, SQORmitochondrial matrixOne of 3 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by MPST, TST, HOGA1mitochondrial matrix, cytosol

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by MPST, TST, PDHA1, PDHB and 1 moremitochondrial matrix, cytosol