sulfite

Three steps

• 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate

  Catalysed by SUOX, ALOXE3mitochondrial matrix, cytosol

• prostaglandin E3Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin E3, Lactate Antiport

  Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• prostaglandin A2Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• prostaglandin B1Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin B1 (cytosol to extracellular)

  Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• prostaglandin J2Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin J2, Lactate Antiport

  Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

  Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• leukotriene F4Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and leukotriene F4 (cytosol to extracellular)

  Catalysed by ETHE1mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• epsilon-(gamma-L-glutamyl)-L-lysineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

  Catalysed by TSTD1, CHAC2, CHAC1, GGACT

• hypothiocyanous acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate:cyanide sulfurtranserase
  3. Dihydrolipoyl Dehydrogenase

  Catalysed by MPST, TST, LPOcytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• all-trans-4-hydroxyretinoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. cytochrome P450 (retinoate)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 3 routes

• a 1,4-benzosemiquinoneReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. 2 a quinone + NADPH + H(+) = 2 a 1,4-benzosemiquinone + NADP(+)

  Catalysed by SLC25A10, SDHB, CRYZ, TP53I3 and 2 moremitochondrial matrix, cytosol

• N-acetylcadaverineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glutathione + H2O = L-cysteinylglycine + L-glutamate
  3. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

  Catalysed by TSTD1, GGT3P, GGT1, GGT5 and 3 more

• all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. glucuronosyltransferase (retinoate)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 7 morecytosol, extracellular space, endoplasmic reticulum

• all-trans-18-hydroxyretinoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. unspecific monooxygenase (retinoate)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 29 morecytosol, extracellular spaceOne of 2 routes

• a phenyl acetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space

• an organic moleculeReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by TSTD1, CP, PRDX6, CYP2D7 and 24 more

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosolOne of 2 routes

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosolOne of 2 routes

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosolOne of 2 routes

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosolOne of 2 routes

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosolOne of 2 routes

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosolOne of 2 routes

• an S-substituted L-cysteinylglycineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
  3. an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate

  Catalysed by TSTD1, GSTT4, GSTA4, GSTZ1 and 25 more

• L-cystine-bis-glycineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glutathione + H2O = L-cysteinylglycine + L-glutamate
  3. 2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

  Catalysed by TSTD1, GGT3P, GGT1, GGT5 and 3 more

• indoxyl sulfateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by TSTD1, GPX1, GPX4, ALOX5

• CHEBI:15345Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by MPST, TST, AACScytosol, mitochondrial matrixOne of 3 routes

• acetoneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by MPST, TSTcytosol, mitochondrial matrix

• cholineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC5A7mitochondrial matrix, cytosol, extracellular space

• acetylcholineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:15519Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. Cholate:CoA ligase (AMP-forming)

  Catalysed by TSTD1, ABCC4, SLC27A2, SLC27A5inner side of the membrane, outer side of the membrane, endoplasmic reticulum

• propionyl-CoAReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)

  Catalysed by MPST, TST, AGXT2, ALDH6A1cytosol, mitochondrial matrixOne of 5 routes

• D-threo-isocitrateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. citrate = D-threo-isocitrate

  Catalysed by SLC25A10, SLC25A1, ACO1, ACO2mitochondrial matrix, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. alanine racemase

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrix

• L-leucineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and leucine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 14 routes

• 15(S)-HPETEReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by MPST, TST, TSTD1, GPX5 and 8 morecytosolOne of 3 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15650Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1B1mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:15699Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and homoserine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• trans-aconitateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SUOX, SLC25A14, SLC26A2, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SUOX, SLC22A6, QPRTmitochondrial matrix, cytosol, extracellular space

• bromideReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by ETHE1, MGST3, GSTA4, GSTA1 and 14 moremitochondrial matrix, cytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SUOX, SLC25A14, SLC25A30, CADmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• beta-nicotinamide D-ribosideReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SLC25A10, SDHB, NQO2mitochondrial matrix, cytosol

• CHEBI:15971Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and histidine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (R)-lactateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (R)-S-lactoylglutathione = methylglyoxal + glutathione
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by TSTD1, GLO1, HAGH

• methanethiolReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by MPST, TST, SELENBP1cytosol