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Proteins/UNIPROT:Q8WV74
Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (By similarity). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)..
Function from UniProtKB (Q8WV74), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
53 statements
53 statements · 5 reference databases · Subject: NUDT8 · Sources: Bgee, Human Protein Atlas, Reactome, Rhea, UniProt
10 reactions
butanoyl-CoA+waterS-butanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:49976CC BY 4.0Reference data
hexanoyl-CoA+waterhexanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate
2 names
Resolves to: NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:49980CC BY 4.0Reference data
octanoyl-CoA+waterS-octanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:50016CC BY 4.0Reference data
an acyl-CoA+wateran acyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or FITM2 or NUDT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50044CC BY 4.0Reference data
coenzyme A(4-)+water(R)-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:64988CC BY 4.0Reference data
acetyl-CoA+waterS-acetyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:64992CC BY 4.0Reference data
propanoyl-CoA+waterpropanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67464CC BY 4.0Reference data
malonyl-CoA+watermalonyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67468CC BY 4.0Reference data
succinyl-CoA+watersuccinyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67472CC BY 4.0Reference data
a 5'-end CoA-ribonucleoside in mRNA+watera 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA+(R)-4'-phosphopantetheine+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT2 or NUDT8 or NUDT16 or NUDT15
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67592CC BY 4.0Reference data