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Proteins/UNIPROT:P0C024
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)..
Function from UniProtKB (P0C024), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
49 statements
49 statements · 5 reference databases · Subject: NUDT7 · Sources: Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt
14 reactions
butanoyl-CoA+waterS-butanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:49976CC BY 4.0Reference data
hexanoyl-CoA+waterhexanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate
2 names
Resolves to: NUDT7
Reaction pageLeft to rightBalanced
Rhea RHEA:49980CC BY 4.0Reference data
octanoyl-CoA+waterS-octanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:50016CC BY 4.0Reference data
decanoyl-CoA+waterdecanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT7
Reaction pageLeft to rightBalanced
Rhea RHEA:50020CC BY 4.0Reference data
dodecanoyl-CoA+waterS-dodecanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50024CC BY 4.0Reference data
tetradecanoyl-CoA+watertetradecanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50028CC BY 4.0Reference data
choloyl-CoA+waterS-choloyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:50036CC BY 4.0Reference data
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+water3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT7
Reaction pageLeft to rightBalanced
Rhea RHEA:50040CC BY 4.0Reference data
coenzyme A(4-)+water(R)-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:64988CC BY 4.0Reference data
acetyl-CoA+waterS-acetyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:64992CC BY 4.0Reference data
propanoyl-CoA+waterpropanoyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67464CC BY 4.0Reference data
malonyl-CoA+watermalonyl-4'-phosphopantetheine+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NUDT19 or NUDT7 or NUDT8
Reaction pageLeft to rightBalanced
Rhea RHEA:67468CC BY 4.0Reference data