CHEBI:16856

Two steps

• hydrogen sulfideReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CTHcytosolOne of 2 routes

• acetateReach from here →
  1. transport of acetylcholine and GSH (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 3 routes

• formic acidReach from here →
  1. alcohol dehydrogenase (formaldehyde)
  2. S-Formylglutathione hydrolase

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 3 morecytosol

• glutarateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• methylarsonateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• thiosulfateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. cystine to cysteine conversion
  2. De novo synthesis of 2Fe2S

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 morecytosol, mitochondrial matrix

• fatty acidReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedextracellular space, cytosolOne of 4 routes

• CHEBI:37946Reach from here →
  1. transport of dopamine and GSH (cytosol to extracellular)
  2. aryl sulfotransferase (dopamine)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 2 moreextracellular space, cytosol

• (R)-lactic acidReach from here →
  1. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  2. (R)-S-Lactoylglutathione hydrolase

  Catalysed by GLO1, GLOD4, HAGH, HAGHLcytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. transport of GSH and prostaglandin A2 (cytosol to extracellular)
  2. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by SLCO2A1extracellular space, cytosolOne of 4 routes

• L-ornithineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• N-methylserotoninReach from here →
  1. transport of GSH and serotonin (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, INMTextracellular space, cytosol

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. transport of GSH and serotonin (cytosol to extracellular)
  2. 5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by SLCO1A2, SLCO1B3, MAOA, MAOBextracellular space, cytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by FAAHextracellular space, cytosol

• malonaldehydeReach from here →
  1. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  2. thromboxane A synthase (12(S)-HHT)

  Catalysed by SLCO2A1, TBXAS1extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. transport of GSH and thyroxine (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3extracellular space, cytosol

• glycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis

  Catalysed by LTC4ScytosolOne of 11 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 moreextracellular space, cytosol

• choloyl-CoAReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosol

• 15-oxoprostaglandin E2Reach from here →
  1. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by SLCO1A2, SLCO1B3, HPGDextracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin E1Reach from here →
  1. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  2. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

  Catalysed by SLCO2A1, CBR3, CBR1, DHRS4extracellular space, cytosolOne of 3 routes

• 15-oxoprostaglandin D2Reach from here →
  1. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  2. 15-dehydro-prostaglandin D2 reduction

  Catalysed by SLCO2A1extracellular space, cytosolOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Glutathione: 15-HPETE oxidoreductase
  2. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by ALOX5, ALOX15, ALOX12extracellular space, cytosol

• thromboxane A2Reach from here →
  1. transport of GSH and thromboxane B2 (cytosol to extracellular)
  2. thromboxane A2 hydrolysis

  Catalysed by SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by ALOX15B, ALOX15, ALOX12extracellular space, cytosol

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by ALOX5extracellular space, cytosol

• L-dopaReach from here →
  1. transport of dopamine and GSH (cytosol to extracellular)
  2. L-dopa + H(+) = dopamine + CO2

  Catalysed by SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• L-histidineReach from here →
  1. transport of GSH and histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2

  Catalysed by SLCO1A2, SLCO1B3, HDCextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. cystine to cysteine conversion
  2. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1cytosolOne of 3 routes

• L-methionineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 8 routes

• L-tryptophanReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• glutathioneReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 16 routes

• L-alanineReach from here →
  1. glutathione gamma-glutamylaminopeptidase
  2. gamma-glutamyltransferase (alanine)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 morecytosolOne of 16 routes

• L-asparagineReach from here →
  1. cystine to cysteine conversion
  2. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 6 routes

• L,L-cystathionineReach from here →
  1. Formation of Homocystine
  2. L-serine hydro-lyase (adding homocysteine

  Catalysed by CBScytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. cystine to cysteine conversion
  2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by GCLC, GCLMcytosolOne of 2 routes

• S-sulfanyl-L-cysteineReach from here →
  1. cystine to cysteine conversion
  2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by CARS2cytosol

• N(tau)-methylhistamineReach from here →
  1. transport of GSH and histamine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, HNMTextracellular space, cytosolOne of 3 routes

• hyodeoxycholateReach from here →
  1. transport of GSH and lithocholate (cytosol to extracellular)
  2. cytochrome P450 (lithocholate)

  Catalysed by SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by FAAH, PM20D1extracellular space, cytosol

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. cystine to cysteine conversion
  2. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by PPCScytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. transport of dopamine and GSH (cytosol to extracellular)
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 9 routes

• 3-sulfino-L-alanineReach from here →
  1. cystine to cysteine conversion
  2. L-Cysteine:oxygen oxidoreductase

  Catalysed by CDO1cytosolOne of 2 routes

• leukotriene D4Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by LTC4S, GGT1, GGT5cytosol

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. cytochrome P450 (arachidonate)

  Catalysed by CYP4F8extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• (R)-adrenalineReach from here →
  1. transport of GSH and noradrenaline (cytosol to extracellular)
  2. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• CHEBI:742324Reach from here →
  1. transport of dopamine and GSH (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, COMT, LRTOMTextracellular space, cytosol