CHEBI:1307929

Three steps

• N-dodecanoylglycineReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 7 moreendoplasmic reticulum, cytosolOne of 2 routes

• N-decanoylglycineReach from here →
  1. Sterol O-Acyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SOAT2, SOAT1, ACSM4, ACSM1 and 5 moreendoplasmic reticulum, cytosolOne of 2 routes

• N-octanoylglycineReach from here →
  1. Sterol O-Acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SOAT2, SOAT1, CROT, GLYATL2endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 3 moreendoplasmic reticulum, mitochondrial matrix

• sn-glycero-3-phosphoethanolamineReach from here →
  1. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  2. a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by CYP46A1, LCAT, PLA2G4Cendoplasmic reticulum

• an N-octadecanoyl-sphingoid baseReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosol

• glycyldehydrophenylalanineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix

• an N-(fatty acyl)-glycineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 1 moreendoplasmic reticulum, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 7 moreendoplasmic reticulum, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 7 moreendoplasmic reticulum, cytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosolOne of 2 routes

• acetaldehydeReach from here →
  1. cytochrome P450 (cholesterol)
  2. cytochrome P450 (pregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by CYP11A1, CYP17A1mitochondrial matrix, cytosolOne of 2 routes

• acetylcholineReach from here →
  1. Sterol O-Acyltransferase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SOAT2, SOAT1, CHATendoplasmic reticulum, nucleus, cytosolOne of 3 routes

• pyruvateReach from here →
  1. Sterol O-Acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SOAT2, SOAT1, AGXT2endoplasmic reticulum, mitochondrial matrixOne of 20 routes

• CHEBI:15467Reach from here →
  1. Sterol O-Acyltransferase
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by SOAT2, SOAT1, AACS, HMGCS1endoplasmic reticulum, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 3 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• (S)-malateReach from here →
  1. 3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase
  2. Cholesterol-sulfate sulfohydrolase
  3. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by SULT2B1, SULT1A3, STS, SLC25A10cytosol, mitochondrial matrixOne of 9 routes

• L-leucineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 21 routes

• CHEBI:15611Reach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, cytosol

• CHEBI:15699Reach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 17 routes

• betaine aldehydeReach from here →
  1. Sterol O-Acyltransferase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by SOAT2, SOAT1, CHAT, CHDHendoplasmic reticulum, nucleus, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. Sterol O-Acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SOAT2, SOAT1, SAT1, SAT2 and 1 moreendoplasmic reticulum, cytosolOne of 2 routes

• malonateReach from here →
  1. 3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase
  2. Cholesterol-sulfate sulfohydrolase
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SULT2B1, SULT1A3, STS, SLC25A14 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 16alpha-hydroxyprogesteroneReach from here →
  1. cytochrome P450 (cholesterol)
  2. Pregnenolone:NAD+ 3-oxidoreductase
  3. progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CYP11A1, HSD3B1, HSD3B2, CYP3A4 and 1 moremitochondrial matrix, cytosol

• 1-acylglycerone 3-phosphateReach from here →
  1. Sterol O-Acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by SOAT2, SOAT1, ASAH1, ACER2 and 3 moreendoplasmic reticulum, Golgi apparatus, cytosol

• CHEBI:15971Reach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 11 routes

• CHEBI:15978Reach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. sn-Glycero-3-phosphocholine glycerophosphohydrolase

  Catalysed by LCAT, LYPLA1, LYPLA2, PLA2G4A and 8 morecytosol

• phosphatidylethanolamineReach from here →
  1. Sterol O-Acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by SOAT2, SOAT1, ASAH1, ACER2 and 7 moreendoplasmic reticulum, Golgi apparatus, cytosol

• 11-cis-retinalReach from here →
  1. Sterol O-Acyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by SOAT2, SOAT1, DGAT1, LRAT and 10 moreendoplasmic reticulum, cytosolOne of 4 routes

• hexadecan-1-olReach from here →
  1. Sterol O-Acyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 8 moreendoplasmic reticulum, cytosol, peroxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. Sterol O-Acyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 11 moreendoplasmic reticulum, cytosolOne of 3 routes

• L-cystineReach from here →
  1. Sterol O-Acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SOAT2, SOAT1, SLC7A9, SLC3A1endoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. Sterol O-Acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SOAT2, SOAT1, AGXT2endoplasmic reticulum, mitochondrial matrix

• phosphatidic acidReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylcholine phosphatidohydrolase

  Catalysed by LCAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 11 routes

• L-citrullineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 4 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• L-valineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 20 routes

• L-arginineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:16523Reach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 3 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 1 moreendoplasmic reticulum, mitochondrial matrix, cytosolOne of 5 routes

• CHEBI:16633Reach from here →
  1. Sterol O-Acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SOAT2, SOAT1, SCLYendoplasmic reticulum, mitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SOAT2, SOAT1, NAGS, MARS1endoplasmic reticulum, mitochondrial matrix, cytosol

• quinolinic acidReach from here →
  1. 3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase
  2. Cholesterol-sulfate sulfohydrolase
  3. Transport of Quinolinic Acid

  Catalysed by SULT2B1, SULT1A3, STS, SLC22A6cytosol, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SOAT2, SOAT1, NAGS, AADATendoplasmic reticulum, mitochondrial matrix

• 2-oxobutanoateReach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by SOAT2, SOAT1, NAGS, CTHendoplasmic reticulum, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16856Reach from here →
  1. Sterol O-Acyltransferase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, ZDHHC11B, NAA10 and 31 moreendoplasmic reticulum, cytosol, extracellular spaceOne of 4 routes

• CHEBI:16857Reach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 4 moreendoplasmic reticulum, mitochondrial matrix, extracellular space, cytosolOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. Sterol O-Acyltransferase
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by SOAT2, SOAT1, ACP2, ENPP3 and 1 moreendoplasmic reticulum, lysosome, cytosolOne of 2 routes

• psychosineReach from here →
  1. Sterol O-Acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by SOAT2, SOAT1, ASAH1, ACER2 and 2 moreendoplasmic reticulum, Golgi apparatus, cytosol

• glyoxylic acidReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 2 moreendoplasmic reticulum, mitochondrial matrix, peroxisome