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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q6PIU2

NCEH1

Protein·UNIPROT:Q6PIU2Neutral cholesterol ester hydrolase 1

Open in the graph

Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration..

Function from UniProtKB (Q6PIU2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

26 statements

26 statements · 4 reference databases · Subject: NCEH1 · Sources: Human Protein Atlas, Reactome, Rhea, WikiPathways

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NCEH1 is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in Ammon's hornAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in colonAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in lungAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in lymph nodeAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in myocardiumAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in placentaAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000144959Inferred only

Show the remaining 14

NCEH1 is expressed in stomachAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in testisAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000144959Inferred only
NCEH1 participates in LDL clearancePathwayReactome R-HSA-8964038Inferred only
NCEH1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
NCEH1 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
NCEH1 participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
NCEH1 participates in Plasma lipoprotein clearancePathwayReactome R-HSA-8964043Inferred only
NCEH1 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
1-O-hexadecyl-2-acetyl-sn-glycerol is a substrate of NCEH1CompoundRhea RHEA:38563Inferred only
a 1-O-alkyl-2-acetyl-sn-glycerol is a substrate of NCEH1CompoundRhea RHEA:11552Inferred only
a cholesterol ester is a substrate of NCEH1CompoundRhea RHEA:36403Inferred only
cholesteryl (9Z-octadecenoate) is a substrate of NCEH1CompoundRhea RHEA:33875Inferred only

Reactions

4 reactions

a 1-O-alkyl-2-acetyl-sn-glycerol+watera 1-O-alkyl-sn-glycerol+acetate+hydron
Catalysed by NCEH1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11552CC BY 4.0Reference data
cholesteryl (9Z-octadecenoate)+watercholesterol+(9Z)-octadecenoate+hydron
Catalysed by CEL or

Other names

6 names

Resolves to: NCEH1

Also called: 2-acetyl MAGE hydrolaseAADACL1Acetylalkylglycerol acetylhydrolaseArylacetamide deacetylase-like 1KIAA1363NCEH

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or LIPA

or LIPE

Reaction pageLeft to rightBalanced

Rhea RHEA:33875CC BY 4.0Reference data

a cholesterol ester+watercholesterol+a fatty acid+hydron

Catalysed by CES1 or LIPN or NCEH1 or LDAH

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:36403CC BY 4.0Reference data

1-O-hexadecyl-2-acetyl-sn-glycerol+water1-O-hexadecyl-sn-glycerol+acetate+hydron

Catalysed by LIPE or NCEH1

Reaction pageLeft to rightBalanced

Rhea RHEA:38563CC BY 4.0Reference data