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Proteins/UNIPROT:Q9UP65
Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency. In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles..
(Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur. Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly..
(Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission..
Function from UniProtKB (Q9UP65), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
85 statements
85 statements · 6 reference databases · Subject: PLA2G4C · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
27 reactions
4 names
Resolves to: PLA2G4C
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum
Human-GEM MAR00463CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00630CC BY 4.0Reference data
water+phosphatidylethanolamineMAM00511c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00643CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome
Human-GEM MAR05254CC BY 4.0Reference data
water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07603CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07615CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G6 or PLA2G4B or LIPC or PLA2G4A or PLB1 or PNPLA7 or ASPG or PNPLA6 or PLA2G15 or PNPLA8 or PLA2G4C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15177CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15801CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G6 or PLA2G4A or PLA2G4F or PLB1 or PAFAH2 or PLA2G4C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36231CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:38779CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:40427CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G6 or LYPLA1 or LYPLA2 or PLA2G4B or LIPC or CEL or PLA2G4A or PLA2G4E or PLA2G4F or PLB1 or PNPLA7 or GDPD3 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40435CC BY 4.0Reference data