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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q86SK9

SCD5

Protein·UNIPROT:Q86SK9Stearoyl-CoA desaturase 5

Open in the graph

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways..

Function from UniProtKB (Q86SK9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

88 statements

88 statements · 7 reference databases · Subject: SCD5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

SCD5 covaries with TMEM59LProteinHetionet hetionet:covaries:25789-79966Inferred only
SCD5 covaries with TRHProteinHetionet hetionet:covaries:7200-79966Inferred only
SCD5 is expressed in adrenal cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in adrenal glandAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in Ammon's hornAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in amygdalaAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in anterior cingulate cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in BrainAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in Brodmann (1909) area 23AnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in Brodmann (1909) area 9AnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in C1 segment of cervical spinal cordAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in caudate nucleusAnatomyBgee ENSG00000145284Inferred only

Show the remaining 76

SCD5 is expressed in cerebellar cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in cerebellar hemisphereAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in cerebellar vermisAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in cerebellumAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in cerebral cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in corpus callosumAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in corpus epididymisAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in dorsal root ganglionAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in dorsolateral prefrontal cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in entorhinal cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in forebrainAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in frontal cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in frontal lobeAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in germinal epithelium of ovaryAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in globus pallidusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in hypothalamusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in inferior vagus X ganglionAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in lateral globus pallidusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in lateral nuclear group of thalamusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in left adrenal glandAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in left adrenal gland cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in medial globus pallidusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in midbrainAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in middle temporal gyrusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in mucosa of urinary bladderAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in neocortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in nucleus accumbensAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in occipital lobeAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in palpebral conjunctivaAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in parietal lobeAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in ponsAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in postcentral gyrusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in prefrontal cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in putamenAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in right adrenal glandAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in right adrenal gland cortexAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in right frontal lobeAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in spinal cordAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in substantia nigra pars compactaAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in substantia nigra pars reticulataAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in subthalamic nucleusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in superior frontal gyrusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in superior vestibular nucleusAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in telencephalonAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in temporal lobeAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in trigeminal ganglionAnatomyBgee ENSG00000145284Inferred only
SCD5 is expressed in ventral tegmental areaAnatomyBgee ENSG00000145284Inferred only
UBC interacts with SCD5ProteinHetionet hetionet:interacts:7316-79966Inferred only
SCD5 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SCD5 participates in EGR2 and SOX10-mediated initiation of Schwann cell myelinationPathwayReactome R-HSA-9619665Inferred only
SCD5 participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
SCD5 participates in Fatty acyl-CoA biosynthesisPathwayReactome R-HSA-75105Inferred only
SCD5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
SCD5 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
SCD5 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SCD5 participates in Omega 9 fatty acid synthesisPathwayWikiPathways WP4724Inferred only
SCD5 requires the cofactor iron(2+)CompoundUniProt Q86SK9Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of SCD5CompoundRhea RHEA:36931Inferred only
(9Z)-octadecenoyl-CoA is a substrate of SCD5CompoundRhea RHEA:19721Inferred only
heptadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02288Inferred only
heptadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02289Inferred only
hexadecanoyl-CoA is a substrate of SCD5CompoundRhea RHEA:36931Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02293Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02294Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02295Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02296Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundRhea RHEA:19721Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02292Inferred only
octadecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02128Inferred only
palmitoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02126Inferred only
palmitoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02287Inferred only
palmitoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02286Inferred only
tetradecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02284Inferred only
tetradecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02281Inferred only
tetradecanoyl-CoA is a substrate of SCD5CompoundHuman-GEM MAR02282Inferred only

Reactions

16 reactions

2MAM01825c+2proton+dioxygen+palmitoyl-CoA2MAM01823c+2water+(9Z)-hexadecenoyl-CoA
Catalysed by SCD or SCD5
Reaction pageLeft to rightBalance undeterminableEC 1.14.19.1cytosol
Human-GEM MAR02126CC BY 4.0Reference data
2MAM01825c+2proton+dioxygen+

Other names

7 names

Resolves to: SCD5

Also called: ACOD4Acyl-CoA-desaturase 4HSCD5SCD2SCD4Stearoyl-CoA 9-desaturaseStearoyl-CoA desaturase 2

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octadecanoyl-CoA

→

2MAM01823c

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalance undeterminableEC 1.14.19.1cytosol

Human-GEM MAR02128CC BY 4.0Reference data

proton+tetradecanoyl-CoA+NADPH(4-)+dioxygenMAM00129c+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02281CC BY 4.0Reference data

proton+tetradecanoyl-CoA+NADPH(4-)+dioxygen(7Z)-tetradecenoyl-CoA+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02282CC BY 4.0Reference data

proton+tetradecanoyl-CoA+NADPH(4-)+dioxygen(5Z)-tetradecenoyl-CoA+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02284CC BY 4.0Reference data

proton+NADPH(4-)+dioxygen+palmitoyl-CoA2water+NADP(3-)+(9Z)-hexadecenoyl-CoA

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02286CC BY 4.0Reference data

proton+NADPH(4-)+dioxygen+palmitoyl-CoA(7Z)-hexadecenoyl-CoA+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02287CC BY 4.0Reference data

proton+heptadecanoyl-CoA+NADPH(4-)+dioxygenMAM00004c+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02288CC BY 4.0Reference data

proton+heptadecanoyl-CoA+NADPH(4-)+dioxygen(9Z)-heptadecenoyl-CoA+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02289CC BY 4.0Reference data

proton+NADPH(4-)+dioxygen+octadecanoyl-CoAMAM00020c+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02292CC BY 4.0Reference data

proton+NADPH(4-)+dioxygen+octadecanoyl-CoAMAM01586c+2water+NADP(3-)

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02293CC BY 4.0Reference data

proton+NADPH(4-)+dioxygen+octadecanoyl-CoA2water+NADP(3-)+oleoyl-CoA

Catalysed by SCD or SCD5

Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol

Human-GEM MAR02294CC BY 4.0Reference data

Show the remaining 4