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Proteins/UNIPROT:P11310
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16..
Function from UniProtKB (P11310), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
255 statements
255 statements · 9 reference databases · Subject: ACADM · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
92 reactions
CHEBI:1146900+water+NAD(+)+4,8-dimethylnonanoyl-CoACHEBI:15351+3proton+NADH(2-)+MAM03553m
Catalysed by ACADM
Reaction pageLeft to rightUnbalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00751CC BY 4.0Reference data
3 names
Resolves to: ACADM
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00752CC BY 4.0Reference data
6CHEBI:1146900+6FAD+6water+6NAD(+)+MAM02689m6CHEBI:15351+6FADH2+6proton+6NADH(2-)+propionyl-CoA
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00755CC BY 4.0Reference data
7CHEBI:1146900+7FAD+7water+7NAD(+)+palmitoyl-CoA8CHEBI:15351+7FADH2+7proton+7NADH(2-)
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00756CC BY 4.0Reference data
4CHEBI:1146900+4FAD+4water+4NAD(+)+palmitoyl-CoA4CHEBI:15351+4FADH2+4proton+4NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00757CC BY 4.0Reference data
(2E)-hexadecenoyl-CoA+4CHEBI:1146900+3FAD+4water+4NAD(+)4CHEBI:15351+3FADH2+4proton+4NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00764CC BY 4.0Reference data
4CHEBI:1146900+3FAD+4water+4NAD(+)+(9Z)-hexadecenoyl-CoA4CHEBI:15351+3FADH2+4proton+4NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00772CC BY 4.0Reference data
7CHEBI:1146900+7FAD+7water+heptadecanoyl-CoA+7NAD(+)7CHEBI:15351+7FADH2+7proton+7NADH(2-)+propionyl-CoA
Catalysed by ACADM
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00774CC BY 4.0Reference data
5CHEBI:1146900+4FAD+5water+5NAD(+)+(11Z)-octadecenoyl-CoA5CHEBI:15351+4FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00780CC BY 4.0Reference data
5CHEBI:1146900+4FAD+5water+5NAD(+)+oleoyl-CoA5CHEBI:15351+4FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00784CC BY 4.0Reference data
5CHEBI:1146900+3FAD+5water+(9Z,12Z)-octadecadienoyl-CoA+5NAD(+)5CHEBI:15351+3FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00785CC BY 4.0Reference data
(9Z,12Z)-octadecadienoyl-CoA+5CHEBI:1146900+3FAD+5water+5NAD(+)5CHEBI:15351+3FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00788CC BY 4.0Reference data