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Proteins/UNIPROT:Q9NRZ7
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. Has a preference for arachidonoyl-CoA as a donor (By similarity). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity)..
Function from UniProtKB (Q9NRZ7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
84 statements
84 statements · 6 reference databases · Subject: AGPAT3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
27 reactions
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51mitochondrial matrix
Human-GEM MAR00580CC BY 4.0Reference data
6 names
Resolves to: AGPAT3
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00588CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00589CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00590CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00591CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00592CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00593CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+MAM01269cCHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00594CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphate+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT2 or GPAT3 or GPAT2 or LCLAT1 or MBOAT2 or LPCAT2 or LPCAT1 or ABHD5 or AGPAT1 or AGPAT4 or AGPAT3 or PNPLA3 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19709CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphate+(9Z)-octadecenoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT2 or GPAT3 or LCLAT1 or MBOAT2 or LPCAT2 or ABHD5 or AGPAT1 or AGPAT3 or AGPAT5
Reaction pageLeft to rightBalanced
Rhea RHEA:33187CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphate+(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:35915CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)+(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAa 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)+coenzyme A(4-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:37015CC BY 4.0Reference data