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Proteins/UNIPROT:Q8WVZ1
Palmitoyltransferase that mediates palmitoylation oproteins, such as RRAS and SQSTM1. Catalyzes palmitoylation of RRAS, leading to increased cell viability. Acts as a positive regulator of autophagy by mediating palmitoylation of SQSTM1, promoting affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Palmitoyltransferase activity may be crucial for spermatogenesis (By similarity)..
(Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation..
Function from UniProtKB (Q8WVZ1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
7 statements
7 statements · 5 reference databases · Subject: ZDHHC19 · Sources: Bgee, gene ontology, Human-GEM, Rhea, WikiPathways
2 reactions
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
2 names
Resolves to: ZDHHC19
Human-GEM MAR01091CC BY 4.0Reference data
L-cysteinyl-[protein]+hexadecanoyl-CoAS-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC11B or GLUL or ZDHHC20 or ZDHHC24 or ZDHHC13 or ZDHHC17 or ZDHHC21 or ZDHHC23 or ZDHHC14 or ZDHHC22 or ZDHHC1 or ZDHHC19 and 13 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36683CC BY 4.0Reference data