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Proteins/UNIPROT:Q8N1Q8
Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function..
Function from UniProtKB (Q8N1Q8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 5 reference databases · Subject: THEM5 · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
water+octadecanoyl-CoACHEBI:1146900+proton+octadecanoate
Catalysed by ACOT7 or ACOT2 or THEM5
Reaction pageReversibleBalancedEC 3.1.2.2mitochondrial matrix
Human-GEM MAR02487CC BY 4.0Reference data
4 names
Resolves to: THEM5
Catalysed by ACOT7 or ACOT8 or PLA2G6 or ACAA2 or ACOT2 or PPT1 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16645CC BY 4.0Reference data
octadecanoyl-CoA+wateroctadecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or ACOT2 or BAAT or MBLAC2 or ACOT1 or THEM5 or ACOT4
Reaction pageLeft to rightBalanced
Rhea RHEA:30139CC BY 4.0Reference data
tetradecanoyl-CoA+watertetradecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or ACAA2 or ACOT2 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 or ACOT11 or ACOT13 and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40119CC BY 4.0Reference data
(9Z)-hexadecenoyl-CoA+water(9Z)-hexadecenoate+coenzyme A(4-)+hydron
Catalysed by ACOT8 or ACOT2 or ACOT1 or THEM5
Reaction pageLeft to rightBalanced
Rhea RHEA:40131CC BY 4.0Reference data
(9Z)-octadecenoyl-CoA+water(9Z)-octadecenoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or ACOT2 or THEM4 or ACOT1 or THEM5 or ACOT4 or ACOT13
Reaction pageLeft to rightBalanced
Rhea RHEA:40139CC BY 4.0Reference data
(9Z,12Z)-octadecadienoyl-CoA+water(9Z,12Z)-octadecadienoate+coenzyme A(4-)+hydron
Catalysed by ACOT8 or ACOT2 or THEM5 or ACOT4
Reaction pageLeft to rightBalanced
Rhea RHEA:40143CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA+water(5Z,8Z,11Z,14Z)-eicosatetraenoate+coenzyme A(4-)+hydron
Catalysed by ACOT8 or THEM4 or THEM5 or ACOT4 or ACOT13
Reaction pageLeft to rightBalanced
Rhea RHEA:40151CC BY 4.0Reference data