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Proteins/UNIPROT:Q9H6R6
Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation..
Function from UniProtKB (Q9H6R6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
417 statements
417 statements · 4 reference databases · Subject: ZDHHC6 · Sources: Bgee, Hetionet, Human-GEM, Rhea · Rows fetched: 300
3 reactions
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
6 names
Resolves to: ZDHHC6
Human-GEM MAR01091CC BY 4.0Reference data
L-cysteinyl-[protein]+hexadecanoyl-CoAS-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC11B or GLUL or ZDHHC20 or ZDHHC24 or ZDHHC13 or ZDHHC17 or ZDHHC21 or ZDHHC23 or ZDHHC14 or ZDHHC22 or ZDHHC1 or ZDHHC19 and 13 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36683CC BY 4.0Reference data
L-cysteinyl-[protein]+octadecanoyl-CoAS-octadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC20 or ZDHHC17 or ZDHHC15 or ZDHHC6 or ZDHHC7 or ZDHHC3 or ZDHHC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59740CC BY 4.0Reference data