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Proteins/UNIPROT:Q68D91
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem)..
Function from UniProtKB (Q68D91), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 3 reference databases · Subject: MBLAC2 · Sources: Hetionet, Rhea, UniProt
5 reactions
hexadecanoyl-CoA+waterhexadecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or PLA2G6 or ACAA2 or ACOT2 or PPT1 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 and 5 more alternatives
4 names
Resolves to: MBLAC2
Rhea RHEA:16645CC BY 4.0Reference data
CHEBI:35627+waterCHEBI:140347
Catalysed by DPEP1 or MBLAC2 or DCLRE1A or DCLRE1B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20401CC BY 4.0Reference data
dodecanoyl-CoA+waterdodecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or ACAA2 or ACOT2 or BAAT or THEM4 or MBLAC2 or ACOT1 or ACOT4 or ACOT11 or ACOT13 or OLAH
Reaction pageLeft to rightBalanced
Rhea RHEA:30135CC BY 4.0Reference data
octadecanoyl-CoA+wateroctadecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or ACOT2 or BAAT or MBLAC2 or ACOT1 or THEM5 or ACOT4
Reaction pageLeft to rightBalanced
Rhea RHEA:30139CC BY 4.0Reference data
tetradecanoyl-CoA+watertetradecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or ACAA2 or ACOT2 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 or ACOT11 or ACOT13 and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40119CC BY 4.0Reference data