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Proteins/UNIPROT:Q5VTY9
Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of hedgehog (DHH, IHH or SHH) morphogens, promoting their maturation. Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where hedgehog palmitoylation occurs. Required for hedgehog signaling during limb development (By similarity). Plays a role in proper testis cord formation and the differentiation of Leydig cells..
Function from UniProtKB (Q5VTY9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
31 statements
31 statements · 5 reference databases · Subject: HHAT · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt
2 reactions
N-terminal L-cysteinyl-[protein]+hexadecanoyl-CoAN-terminal N-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)+hydron
Catalysed by HHAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59528CC BY 4.0Reference data
N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester+hexadecanoyl-CoAN-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester+coenzyme A(4-)+hydron
Catalysed by HHAT
6 names
Resolves to: HHAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59580CC BY 4.0Reference data