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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8WTS1

ABHD5

Protein·UNIPROT:Q8WTS11-acylglycerol-3-phosphate O-acyltransferase ABHD5

Open in the graph

Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity)..

Function from UniProtKB (Q8WTS1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

Dorfman-Chanarin disease has a germline basis in ABHD5DiseaseGenCC HGNC:21396|MONDO:0010155Inferred only

Statements

43 statements

43 statements · 6 reference databases · Subject: ABHD5 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

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PLIN1 interacts with ABHD5ProteinHetionet hetionet:interacts:51099-5346Inferred only
PLIN2 interacts with ABHD5ProteinHetionet hetionet:interacts:123-51099Inferred only
UBC interacts with ABHD5ProteinHetionet hetionet:interacts:51099-7316Inferred only
ABHD5 participates in 5q35 copy number variationPathwayWikiPathways WP5380Inferred only
ABHD5 participates in Lipid metabolism pathwayPathwayWikiPathways WP3965Inferred only
ABHD5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ABHD5 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ABHD5 participates in Triglyceride catabolismPathwayReactome R-HSA-163560Inferred only
ABHD5 participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
ABHD5 regulates positive regulation of triglyceride catabolic processBiological processgene ontology Q8WTS1|GO:0010898Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37443Inferred only
(9Z)-octadecenoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:33187Inferred only

Show the remaining 31

(9Z)-octadecenoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37455Inferred only
(9Z)-octadecenoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37131Inferred only
(9Z)-octadecenoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37163Inferred only
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37455Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37131Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37451Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37443Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37147Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37143Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00592Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00593Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00594Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00580Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00588Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00589Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00590Inferred only
1-acyl-sn-glycerol 3-phosphate is a substrate of ABHD5CompoundHuman-GEM MAR00591Inferred only
1-hexadecanoyl-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:33187Inferred only
1-octadecanoyl-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:37163Inferred only
a 1-acyl-sn-glycero-3-phosphate is a substrate of ABHD5CompoundRhea RHEA:19709Inferred only
an acyl-CoA is a substrate of ABHD5CompoundRhea RHEA:19709Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00580Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00588Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00589Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00590Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00591Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00592Inferred only
an acyl-CoA is a substrate of ABHD5CompoundHuman-GEM MAR00593Inferred only
eicosanoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37451Inferred only
hexadecanoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37143Inferred only
octadecanoyl-CoA is a substrate of ABHD5CompoundRhea RHEA:37147Inferred only

Reactions

17 reactions

1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51mitochondrial matrix
Human-GEM MAR00580CC BY 4.0Reference data

Other names

3 names

Resolves to: ABHD5

Also called: Abhydrolase domain-containing protein 5Lipid droplet-binding protein CGI-58NCIE2

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1-acyl-sn-glycerol 3-phosphate

→

+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00588CC BY 4.0Reference data

1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00589CC BY 4.0Reference data

1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00590CC BY 4.0Reference data

1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00591CC BY 4.0Reference data

1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00592CC BY 4.0Reference data

1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00593CC BY 4.0Reference data

1-acyl-sn-glycerol 3-phosphate+MAM01269cCHEBI:1146900+phosphatidic acid

Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1

Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol

Human-GEM MAR00594CC BY 4.0Reference data

a 1-acyl-sn-glycero-3-phosphate+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphate+coenzyme A(4-)

Catalysed by AGPAT2 or GPAT3 or GPAT2 or LCLAT1 or MBOAT2 or LPCAT2 or LPCAT1 or ABHD5 or AGPAT1 or AGPAT4 or AGPAT3 or PNPLA3 and 1 more alternative

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:19709CC BY 4.0Reference data

1-hexadecanoyl-sn-glycero-3-phosphate+(9Z)-octadecenoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)

Catalysed by AGPAT2 or GPAT3 or LCLAT1 or MBOAT2 or LPCAT2 or ABHD5 or AGPAT1 or AGPAT3 or AGPAT5

Reaction pageLeft to rightBalanced

Rhea RHEA:33187CC BY 4.0Reference data

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+(9Z)-octadecenoyl-CoA1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)

Catalysed by AGPAT2 or GPAT3 or GPAT2 or LCLAT1 or LPCAT2 or ABHD5 or AGPAT1 or AGPAT3 or PNPLA3 or AGPAT5

Reaction pageLeft to rightBalanced

Rhea RHEA:37131CC BY 4.0Reference data

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hexadecanoyl-CoA1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate+coenzyme A(4-)

Catalysed by AGPAT2 or GPAT3 or LCLAT1 or LPCAT2 or ABHD5 or AGPAT1 or PNPLA3

Reaction pageLeft to rightBalanced

Rhea RHEA:37143CC BY 4.0Reference data

Show the remaining 5