Loading the page.
Proteins/UNIPROT:Q5W0Z9
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. Palmitoylates TRIM28 and thereby plays an important role in the DNA damage repair response..
(Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell..
Function from UniProtKB (Q5W0Z9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
74 statements
74 statements · 4 reference databases · Subject: ZDHHC20 · Sources: Bgee, Hetionet, Reactome, Rhea
3 reactions
L-cysteinyl-[protein]+hexadecanoyl-CoAS-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC11B or GLUL or ZDHHC20 or ZDHHC24 or ZDHHC13 or ZDHHC17 or ZDHHC21 or ZDHHC23 or ZDHHC14 or ZDHHC22 or ZDHHC1 or ZDHHC19 and 13 more alternatives
Reaction pageLeft to rightBalance undeterminable
4 names
Resolves to: ZDHHC20
Rhea RHEA:36683CC BY 4.0Reference data
L-cysteinyl-[protein]+tetradecanoyl-CoAS-tetradecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC20 or ZDHHC17 or ZDHHC15 or ZDHHC7 or ZDHHC3 or ZDHHC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59736CC BY 4.0Reference data
L-cysteinyl-[protein]+octadecanoyl-CoAS-octadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC20 or ZDHHC17 or ZDHHC15 or ZDHHC6 or ZDHHC7 or ZDHHC3 or ZDHHC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59740CC BY 4.0Reference data