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Proteins/UNIPROT:Q9ULC5
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells..
Function from UniProtKB (Q9ULC5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
260 statements
260 statements · 9 reference databases · Subject: ACSL5 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
156 reactions
ATP+CHEBI:1146900+dodecanoateAMP+dodecanoyl-CoA+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00188CC BY 4.0Reference data
5 names
Resolves to: ACSL5
ATP+CHEBI:1146900+MAM03051cAMP+diphosphate(3-)+MAM03050c
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00192CC BY 4.0Reference data
ATP+CHEBI:1146900+tetradecanoateAMP+tetradecanoyl-CoA+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00196CC BY 4.0Reference data
MAM00128c+ATP+CHEBI:1146900MAM00129c+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00200CC BY 4.0Reference data
MAM00117c+ATP+CHEBI:1146900(7Z)-tetradecenoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00204CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM02745c(5Z)-tetradecenoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00209CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM02690cAMP+MAM02689c+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00213CC BY 4.0Reference data
ATP+CHEBI:1146900+hexadecanoic acidAMP+palmitoyl-CoA+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00217CC BY 4.0Reference data
ATP+CHEBI:1146900+(9Z)-hexadecenoateAMP+(9Z)-hexadecenoyl-CoA+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00226CC BY 4.0Reference data
MAM01197c+ATP+CHEBI:1146900(7Z)-hexadecenoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00233CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM02456cAMP+heptadecanoyl-CoA+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00237CC BY 4.0Reference data
MAM00003c+ATP+CHEBI:1146900MAM00004c+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00241CC BY 4.0Reference data