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Proteins/UNIPROT:Q9H8X9
Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). May play a role in cell proliferation..
Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response. Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response..
Function from UniProtKB (Q9H8X9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 6 reference databases · Subject: ZDHHC11 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
4 names
Resolves to: ZDHHC11
Human-GEM MAR01088CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-nucleus
Human-GEM MAR01091CC BY 4.0Reference data
L-cysteinyl-[protein]+hexadecanoyl-CoAS-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC11B or GLUL or ZDHHC20 or ZDHHC24 or ZDHHC13 or ZDHHC17 or ZDHHC21 or ZDHHC23 or ZDHHC14 or ZDHHC22 or ZDHHC1 or ZDHHC19 and 13 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36683CC BY 4.0Reference data