Compound

3-oxooctadecanoyl-CoA

A 3-oxo-fatty acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate groups of 3-oxooctadecanoyl-CoA; major species at pH 7.3.

Definition from ChEBI (CHEBI:71407), read 2026-09-23. CC BY 4.0.

CHEBI:71407ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C39H64N7O18P3S
Mass: 1043.961 g/mol
Charge: -4
InChIKey: LGOGWHDPDVAUNY-LFZQUHGESA-J
SMILES: CCCCCCCCCCCCCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: 3-oxooctadecanoyl-CoA · Sources: Human-GEM, Rhea

Order

3-oxooctadecanoyl-CoA is converted to hexadecanoyl-CoACompoundRhea RHEA:35279Inferred only
hexadecanoyl-CoA is converted to 3-oxooctadecanoyl-CoACompoundRhea RHEA:35315Inferred only
3-oxooctadecanoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR03077Inferred only
3-oxooctadecanoyl-CoA is a substrate of ACAA2ProteinHuman-GEM MAR03118Inferred only
3-oxooctadecanoyl-CoA is a substrate of ELOVL1ProteinHuman-GEM MAR02521Inferred only
3-oxooctadecanoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03118Inferred only
3-oxooctadecanoyl-CoA is a substrate of HADHBProteinHuman-GEM MAR03118Inferred only
3-oxooctadecanoyl-CoA is a substrate of HADHBProteinRhea RHEA:35279Inferred only
3-oxooctadecanoyl-CoA is a substrate of HSD17B12ProteinHuman-GEM MAR02191Inferred only
3-oxooctadecanoyl-CoA is a substrate of HSD17B12ProteinRhea RHEA:39151Inferred only
3-oxooctadecanoyl-CoA is a substrate of MYO5BProteinHuman-GEM MAR03077Inferred only
3-oxooctadecanoyl-CoA is a substrate of SCP2ProteinRhea RHEA:35279Inferred only

Reactions

15 reactions

proton+malonyl-CoA+palmitoyl-CoA3-oxooctadecanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02190CC BY 4.0Reference data
3-oxooctadecanoyl-CoA+proton+NADPH(4-)MAM00793c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02191CC BY 4.0Reference data
proton+malonyl-CoA+palmitoyl-CoA3-oxooctadecanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199endoplasmic reticulum
Human-GEM MAR02519CC BY 4.0Reference data
3-oxooctadecanoyl-CoA+proton+NADPH(4-)MAM00793r+NADP(3-)
Catalysed by ELOVL1
Reaction pageReversibleBalancedEC 2.7.4.9endoplasmic reticulum
Human-GEM MAR02521CC BY 4.0Reference data
MAM00793x+NAD(+)3-oxooctadecanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03076CC BY 4.0Reference data
3-oxooctadecanoyl-CoA+CHEBI:1146900CHEBI:15351+palmitoyl-CoA
Catalysed by ACAA1 & MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03077CC BY 4.0Reference data
MAM00793m+NAD(+)3-oxooctadecanoyl-CoA+proton+NADH(2-)
Catalysed by HADHA & HADH & HSD17B10
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211mitochondrial matrix
Human-GEM MAR03117CC BY 4.0Reference data
3-oxooctadecanoyl-CoA+CHEBI:1146900CHEBI:15351+palmitoyl-CoA
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR03118CC BY 4.0Reference data
CHEBI:71408+NAD(1-)3-oxooctadecanoyl-CoA+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:35275CC BY 4.0Reference data
hexadecanoyl-CoA+acetyl-CoA3-oxooctadecanoyl-CoA+coenzyme A(4-)
Catalysed by SCP2 or HADHB
Reaction pageRight to leftBalanced
Rhea RHEA:35279CC BY 4.0Reference data
CHEBI:71408+NADP(3-)3-oxooctadecanoyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:35299CC BY 4.0Reference data
hexadecanoyl-CoA+malonyl-CoA+hydron3-oxooctadecanoyl-CoA+carbon dioxide+coenzyme A(4-)
Catalysed by ELOVL7 or ELOVL6 or ELOVL3
Reaction pageLeft to rightBalanced
Rhea RHEA:35315CC BY 4.0Reference data

Show the remaining 3

Other names

15 names

Resolves to: 3-oxooctadecanoyl-CoA

Also called: 3-ketooctadecanoyl-CoA(4-)3-ketooctadecanoyl-CoA(4−)3-ketooctadecanoyl-coenzyme A(4-)3-ketooctadecanoyl-coenzyme A(4−)3-ketostearoyl-CoA(4-)3-ketostearoyl-CoA(4−)3-ketostearoyl-coenzyme A(4-)3-ketostearoyl-coenzyme A(4−)3-oxooctadecanoyl-coenzyme A(4-)3-oxooctadecanoyl-coenzyme A(4−)3-oxostearoyl-CoA(4-)3-oxostearoyl-CoA(4−)3-oxostearoyl-coenzyme A(4-)3-oxostearoyl-coenzyme A(4−)
Systematic name: 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxooctadecanoyl)sulfanyl]ethyl}amino)propyl]amino}butyl] diphosphate}