Loading the page.
Proteins/UNIPROT:P49753
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity)..
Function from UniProtKB (P49753), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
134 statements
134 statements · 7 reference databases · Subject: ACOT2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
56 reactions
water+palmitoyl-CoACHEBI:1146900+proton+hexadecanoic acid
Catalysed by ACOT7 or ACOT2 or PPT1 or BAAT or ACOT4 or ACOT1 or ACOT6 or PPT2 or EGFL8
Reaction pageLeft to rightBalancedEC 3.1.2.2, 3.1.2.22peroxisome
Human-GEM MAR00709CC BY 4.0Reference data
7 names
Resolves to: ACOT2
MAM00279c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01219c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01065CC BY 4.0Reference data
MAM01219c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01176c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01066CC BY 4.0Reference data
MAM01176c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01055c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 11 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01067CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00310c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01068CC BY 4.0Reference data
MAM00310c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00259c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01069CC BY 4.0Reference data
MAM00259c+ATP+CHEBI:1146900+proton+2water+NAD(+)+dioxygenMAM01210c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01070CC BY 4.0Reference data
MAM00836m+waterMAM00835m+CHEBI:1146900+proton
Catalysed by ACOT7 or ACOT2 or BAAT or ACOT4 or ACOT1 or ACOT6
Reaction pageLeft to rightBalancedEC 3.1.2.2mitochondrial matrix
Human-GEM MAR01170CC BY 4.0Reference data
MAM00836x+waterMAM00835x+CHEBI:1146900+proton
Catalysed by ACOT7 or ACOT2 or BAAT or ACOT4 or ACOT1 or ACOT6
Reaction pageLeft to rightBalancedEC 3.1.2.2peroxisome
Human-GEM MAR01171CC BY 4.0Reference data
MAM00838m+waterMAM00837m+CHEBI:1146900+proton
Catalysed by ACOT7 or ACOT2 or BAAT or ACOT4 or ACOT1 or ACOT6
Reaction pageLeft to rightBalancedEC 3.1.2.2mitochondrial matrix
Human-GEM MAR01212CC BY 4.0Reference data
MAM00838x+waterMAM00837x+CHEBI:1146900+proton
Catalysed by ACOT7 or ACOT2 or BAAT or ACOT4 or ACOT1 or ACOT6
Reaction pageLeft to rightBalancedEC 3.1.2.2peroxisome
Human-GEM MAR01213CC BY 4.0Reference data
MAM00421m+waterCHEBI:1146900+proton+MAM02649m
Catalysed by ACOT7 or ACOT2 or BAAT or ACOT4 or ACOT1 or ACOT6
Reaction pageLeft to rightBalancedEC 3.1.2.2mitochondrial matrix
Human-GEM MAR01261CC BY 4.0Reference data