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Proteins/UNIPROT:Q9Y397
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD..
(Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell..
Function from UniProtKB (Q9Y397), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
28 statements
28 statements · 6 reference databases · Subject: ZDHHC9 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
9 names
Resolves to: ZDHHC9
Human-GEM MAR01088CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-nucleus
Human-GEM MAR01091CC BY 4.0Reference data
L-cysteinyl-[protein]+hexadecanoyl-CoAS-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC11B or GLUL or ZDHHC20 or ZDHHC24 or ZDHHC13 or ZDHHC17 or ZDHHC21 or ZDHHC23 or ZDHHC14 or ZDHHC22 or ZDHHC1 or ZDHHC19 and 13 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36683CC BY 4.0Reference data