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Proteins/UNIPROT:Q9NUE0
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling..
Function from UniProtKB (Q9NUE0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 statements
6 statements · 4 reference databases · Subject: ZDHHC18 · Sources: Bgee, gene ontology, Hetionet, Rhea
1 reaction
L-cysteinyl-[protein]+hexadecanoyl-CoAS-hexadecanoyl-L-cysteinyl-[protein]+coenzyme A(4-)
Catalysed by ZDHHC11B or GLUL or ZDHHC20 or ZDHHC24 or ZDHHC13 or ZDHHC17 or ZDHHC21 or ZDHHC23 or ZDHHC14 or ZDHHC22 or ZDHHC1 or ZDHHC19 and 13 more alternatives
Reaction pageLeft to rightBalance undeterminable
3 names
Resolves to: ZDHHC18
Rhea RHEA:36683CC BY 4.0Reference data