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Proteins/UNIPROT:Q6P1M0
Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity)..
Function from UniProtKB (Q6P1M0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · substrate of, transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
1 row
112 statements
112 statements · 7 reference databases · Subject: SLC27A4 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
115 reactions
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 or FABP12 and 1 more alternative
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00155CC BY 4.0Reference data
8 names
Resolves to: SLC27A4
Transported by FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 or FABP12 and 1 more alternative
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00164CC BY 4.0Reference data
MAM02120eMAM02120c
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00167CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00170CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00173CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00176CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00179CC BY 4.0Reference data
MAM03117eMAM03117c
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00183CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR00187CC BY 4.0Reference data
MAM03051eMAM03051c
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR00191CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR00195CC BY 4.0Reference data
MAM00128eMAM00128c
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR00199CC BY 4.0Reference data