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Proteins/UNIPROT:Q96PD7
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG)..
Function from UniProtKB (Q96PD7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
68 statements
68 statements · 7 reference databases · Subject: DGAT2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
a 1,2-diacyl-sn-glycerol+an acyl-CoACHEBI:1146900+a triacylglycerol
Catalysed by DGAT2 or MOGAT3 or MOGAT1 or MOGAT2 or DGAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.20, 2.3.1.22cytosol
Human-GEM MAR00605CC BY 4.0Reference data
1,2-diacyl-sn-glycero-3-phosphocholine(1+)+all-trans-retinolMAM00535c+
4 names
Resolves to: DGAT2
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135, 2.3.1.75cytosol
Human-GEM MAR06635CC BY 4.0Reference data
11-cis-retinol+1,2-diacyl-sn-glycero-3-phosphocholine(1+)MAM00535c+an all-trans-retinyl ester
Catalysed by DGAT2 or RBP2 or RBP1 or LRAT or AWAT2 or DGAT1 or AWAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135, 2.3.1.75cytosol
Human-GEM MAR06639CC BY 4.0Reference data
11-cis-retinol+palmitoyl-CoA11-cis-retinyl hexadecanoate+CHEBI:1146900
Catalysed by DGAT2 or LRAT or AWAT2 or DGAT1 or AWAT1
Reaction pageReversibleBalancedEC 2.3.1.75, 2.3.1.76, 2.3.1.135cytosol
Human-GEM MAR06671CC BY 4.0Reference data
an acyl-CoA+a 1,2-diacyl-sn-glycerola triacyl-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT2 or MOGAT3 or TMEM68 or DGAT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10868CC BY 4.0Reference data
all-trans-retinol+an acyl-CoAan all-trans-retinyl ester+coenzyme A(4-)
Catalysed by DGAT1 or PNPLA4 or AWAT2 or DGAT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11488CC BY 4.0Reference data
2-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoyl-CoA1,2-di-(9Z-octadecenoyl)-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:37911CC BY 4.0Reference data
1-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoyl-CoA1,2-di-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT2 or DGAT2L6 or MOGAT1 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:37915CC BY 4.0Reference data
2-(9Z-octadecenoyl)-glycerol+hexadecanoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or AWAT2 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38071CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+hexadecanoyl-CoA1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or AWAT2 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38163CC BY 4.0Reference data
all-trans-retinol+hexadecanoyl-CoAall-trans-retinyl hexadecanoate+coenzyme A(4-)
Catalysed by DGAT1 or PNPLA4 or AWAT2 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38175CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+(9Z)-octadecenoyl-CoA1,2,3-tri-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT1 or AWAT2 or DGAT2L6 or MOGAT3 or TMEM68 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38219CC BY 4.0Reference data