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Proteins/UNIPROT:O15254
Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs). Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product. Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3. Can oxidize straight-chain mono- and dicarboxylyl fatty acyl-CoAs with lower efficiency (By similarity)..
Oxidizes the CoA-esters of 2-methyl-branched fatty acids..
Function from UniProtKB (O15254), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
87 statements
87 statements · 6 reference databases · Subject: ACOX3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
87 reactions
MAM00279c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01219c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or
5 names
Resolves to: ACOX3
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01065CC BY 4.0Reference data
MAM01219c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01176c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01066CC BY 4.0Reference data
MAM01176c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01055c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 11 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01067CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00310c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01068CC BY 4.0Reference data
MAM00310c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00259c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01069CC BY 4.0Reference data
MAM00259c+ATP+CHEBI:1146900+proton+2water+NAD(+)+dioxygenMAM01210c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01070CC BY 4.0Reference data
MAM01120m+dioxygenMAM01119m+hydrogen peroxide
Reaction pageLeft to rightBalancedEC 1.3.3.6mitochondrial matrix
Human-GEM MAR01161CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 1.3.3.6peroxisome
Human-GEM MAR01162CC BY 4.0Reference data
MAM01201m+dioxygenMAM01199m+hydrogen peroxide
Reaction pageLeft to rightBalancedEC 1.3.3.6mitochondrial matrix
Human-GEM MAR01175CC BY 4.0Reference data
MAM01146m+dioxygenMAM01144m+hydrogen peroxide
Reaction pageLeft to rightBalancedEC 1.3.3.6mitochondrial matrix
Human-GEM MAR01180CC BY 4.0Reference data
MAM01122m+dioxygenMAM01121m+hydrogen peroxide
Reaction pageLeft to rightBalancedEC 1.3.3.6mitochondrial matrix
Human-GEM MAR01204CC BY 4.0Reference data
Catalysed by ACOX3
Reaction pageLeft to rightBalancedEC 1.3.3.6peroxisome
Human-GEM MAR01205CC BY 4.0Reference data