19-oxo-androst-4-ene-3,17-dione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

165 compounds within 3 steps: 3 in 1, 26 in 2, 136 in 3

One step

formateReach from here →
1. 19-oxo-androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = estrone + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Catalysed by CYP19A1
estroneReach from here →
1. cytochrome P450 (19-oxoandrostenedione)
Catalysed by CYP19A1cytosolOne of 2 routes
formic acidReach from here →
1. cytochrome P450 (19-oxoandrostenedione)
Catalysed by CYP19A1cytosol

Two steps

2-hydroxybutyric acidReach from here →
1. cytochrome P450 (19-oxoandrostenedione)
2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes
2-hydroxyestroneReach from here →
1. cytochrome P450 (19-oxoandrostenedione)
2. cytochrome P450 (estrone)
Catalysed by CYP19A1, CYP3A4cytosolOne of 4 routes

Three steps

estrone 3-O-(beta-D-glucuronate)

Reach from here →

Catalysed by CYP19A1, UGT1A1, UGT1A10, UGT1A8cytosol, endoplasmic reticulumOne of 2 routes

acetoacetateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by CYP19A1, MTHFD1cytosolOne of 2 routes

17beta-estradiolReach from here →

Catalysed by CYP19A1, HSD17B6, HSD17B1, HSD17B2 and 4 morecytosolOne of 5 routes

formaldehydeReach from here →

Catalysed by CYP19A1, ALDH9A1

(R)-3-hydroxybutyric acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

17alpha-estradiolReach from here →

Catalysed by CYP19A1, DHRS1cytosol

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by CYP19A1, MTHFD1, MTHFD1L

chlorine(.)Reach from here →

Catalysed by CYP19A1, SLC26A4cytosol, extracellular spaceOne of 2 routes

acetateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

oxalateReach from here →

Catalysed by CYP19A1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

propionic acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

(S)-lactic acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →

Catalysed by CYP19A1, ADI1One of 2 routes

S-formylglutathioneReach from here →

Catalysed by CYP19A1, ESD

N-formyl-L-kynurenineReach from here →

Catalysed by CYP19A1, AFMID

estrone 3-sulfateReach from here →

Catalysed by CYP19A1, SULT1A3, SULT1E1, SULT1A1cytosolOne of 3 routes

16alpha-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP2E1 and 20 morecytosolOne of 3 routes

4-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP3A4 and 3 morecytosol

6alpha-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1cytosol

15alpha-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1cytosol

Catalysed by CYP19A1, SLC26A4, SLC6A14

cytosol, extracellular space

2-methoxyestroneReach from here →

Catalysed by CYP19A1, CYP3A4, COMT, LRTOMTcytosolOne of 3 routes

prostaglandin E3Reach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by CYP19A1, SULT1A3, SULT1E1, SULT1A1 and 1 morecytosol, extracellular spaceOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, CYP26A1cytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

17beta-estradiol 3-sulfateReach from here →

Catalysed by CYP19A1, HSD17B6, HSD17B1, HSD17B2 and 7 morecytosol

16alpha-hydroxyestrone 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP2E1 and 21 morecytosol

16alpha-hydroxyestrone 16-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP2E1 and 21 morecytosol

17beta-estradiol 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, HSD17B6, HSD17B1, HSD17B2 and 24 morecytosol, endoplasmic reticulumOne of 2 routes

17alpha-estradiol 17-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, DHRS1, UGT2B17, UGT2B4 and 2 morecytosol

2-hydroxyestrone 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, CYP3A4, UGT1A9, UGT1A1 and 1 morecytosol

4-hydroxyestrone 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP3A4 and 4 morecytosol

estrone 4-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP3A4 and 6 morecytosol

4-methoxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP3A4 and 4 morecytosol

2-hydroxy-3-methoxy-estroneReach from here →

Catalysed by CYP19A1, CYP3A4, COMTcytosol

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, UGT1A1 and 2 morecytosol, extracellular space, endoplasmic reticulum