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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Articles Pathways Processes Anatomy Cell types Organisms Materials Assessments

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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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Reference layer

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Reaction

estrone+reduced [NADPH--hemoprotein reductase]+dioxygen4-hydroxyestrone+oxidized [NADPH--hemoprotein reductase]+water+hydron

Left to right · Balance undeterminable

Inferred

Reference data, not a finding. Evidence key

Catalysts

CYP1A1
CYP1A2
CYP3A4
CYP3A5
CYP3A7
CYP1B1

Rhea RHEA:47292·2026-08-19·CC BY 4.0Reference data