Compound

4-methoxyestrone

A 17-oxo steroid that is estrone in which the hydrogen at position 4 has been replaced by a methoxy group.

Definition from ChEBI (CHEBI:136972), read 2026-09-23. CC BY 4.0.

CHEBI:136972ChEBI

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Structure

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A generated conformer of 4-methoxyestrone — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C19H24O3
Mass: 300.398 g/mol
Charge: 0
InChIKey: PUEXVLNGOBYUEW-BFDPJXHCSA-N
SMILES: [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(O)c(OC)c3CC[C@@]21[H]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Chemical structure

4-methoxyestrone has the functional parent estroneCompoundChEBI CHEBI:136972Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: 4-methoxyestrone · Sources: Human-GEM, Rhea

Order

4-hydroxyestrone is converted to 4-methoxyestroneCompoundRhea RHEA:53104Inferred only
4-methoxyestrone is converted to 4-methoxyestrone 3-O-(beta-D-glucuronate)CompoundRhea RHEA:53068Inferred only
4-methoxyestrone is metabolised by COMTProteinHuman-GEM MAR02052Inferred only
4-methoxyestrone is metabolised by UGT1A8ProteinRhea RHEA:53068Inferred only
4-methoxyestrone is a substrate of LRTOMTProteinHuman-GEM MAR02052Inferred only

Reactions

4 reactions

16alpha-hydroxyestrone+16alpha-hydroxyestrone+MAM00432r+MAM00604c+MAM00624c+MAM00641c+MAM00641m+MAM00641r+MAM00641x+MAM00642c+MAM00642m+MAM00642r+MAM00642x+MAM00644c+MAM00645c+2-hydroxy-17beta-estradiol+2-hydroxy-17beta-estradiol+MAM00651c+MAM00651m+MAM00651r+MAM00651x+MAM00652c+MAM00652m+MAM00652r+MAM00652x+2-methoxy-17beta-estradiol+2-methoxyestrone+2-methoxyestrone+MAM00747r+MAM00828r+MAM00830c+MAM00925c+MAM00927c+MAM00945c+MAM00947c+MAM00949c+MAM00987c+MAM00987m+MAM00987r+MAM00987x+(E)-4-hydroxynon-2-enal+MAM01001c+MAM01001m+MAM01001r+MAM01001x+MAM01011c+4-methoxyestrone+3alpha-hydroxy-5alpha-pregnan-20-one+MAM01792r+MAM01794r+MAM02469cMAM10001e
Reaction pageLeft to rightBalance undeterminablecytosol, endoplasmic reticulum, mitochondrial matrix, peroxisome, lysosome, extracellular space
Human-GEM MAR00037CC BY 4.0Reference data
MAM01000c+S-adenosyl-L-methionine4-methoxyestrone+proton+CHEBI:16680
Catalysed by COMT or LRTOMT
Reaction pageReversibleBalancedEC 2.1.1.6cytosol
Human-GEM MAR02052CC BY 4.0Reference data
4-methoxyestrone+UDP-alpha-D-glucuronate4-methoxyestrone 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:53068CC BY 4.0Reference data
4-hydroxyestrone+S-adenosyl-L-methionine4-methoxyestrone+S-adenosyl-L-homocysteine+hydron
Catalysed by COMT
Reaction pageLeft to rightBalanced
Rhea RHEA:53104CC BY 4.0Reference data

Other names

5 names

Resolves to: 4-methoxyestrone

Also called: 4-Hydroxyestrone-4-methyl ether4-MeOE14-methoxy-estra-1,3,5(10)-trien-3-ol-17-oneST 19:4;O3
Systematic name: 3-hydroxy-4-methoxyestra-1,3,5(10)-trien-17-one