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Proteins/UNIPROT:O15229
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)..
Function from UniProtKB (O15229), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 8 reference databases · Subject: KMO · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
CHEBI:17380+water+NADP(3-)proton+L-kynurenine+NADPH(4-)+dioxygen
Catalysed by KMO
Reaction pageReversibleBalancedEC 1.14.13.9cytosol
Human-GEM MAR04220CC BY 4.0Reference data
1 name
Resolves to: KMO
Catalysed by KMO
Reaction pageDirection not assertedBalanced
Rhea RHEA:20545CC BY 4.0Reference data