N(6)-(1,2-dicarboxyethyl)-AMP

Three steps

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ADSS2, ADSS1, NAT8L, HADHA and 2 moremitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ADSS2, ADSS1, NAT8L, ECHS1 and 2 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ADSS2, ADSS1, NAT8L, ECHS1 and 2 moremitochondrial matrixOne of 2 routes

• a quinolReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by ADSL, TNRC6B, FH, SDHB and 1 morecytosolOne of 13 routes

• folic acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Folate Transport by Oats

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC22A8 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• CHEBI:27540Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ADSS2, ADSS1, NAT8L, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ADSS2, ADSS1, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by ADSS2, ADSS1, SLC7A13, TPH1 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ADSS2, ADSS1, NAT8L, ACAA1 and 2 moremitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ADSS2, ADSS1, AGXT2, SCLYcytosol

• 3-disulfanyl-L-alanineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by ADSS2, ADSS1, SLC7A13, CTHinner side of the membrane, outer side of the membrane, cytosol

• CHEBI:28862Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. dGMP + inosine = 2'-deoxyguanosine + IMP
  3. ATP:dGMP phosphotransferase

  Catalysed by ADSS2, ADSS1, NT5C2, GUK1cytosolOne of 2 routes

• a dicarboxylateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A35 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2'-deoxyinosineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. dIMP + inosine = 2'-deoxyinosine + IMP

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 2 moreOne of 4 routes

• Ca(2+)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, SLC1A7, SLC1A3 and 8 moreextracellular space, cytosolOne of 3 routes

• Phe-tRNA(Phe)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ADSS2, ADSS1, SLC7A13, FARSB and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by ADSS2, ADSS1, SLC7A13, WARS1inner side of the membrane, outer side of the membrane, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by ADSS2, ADSS1, SLC7A13, QARS1inner side of the membrane, outer side of the membrane, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by ADSS2, ADSS1, ASNS, NARS1cytosol

• chlorine(.)Reach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC26A6cytosol, mitochondrial matrix, extracellular spaceOne of 22 routes

• hydrogen sulfideReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by ADSL, TNRC6B, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

• D-aspartateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• acetateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N-Acetyl-L-aspartate amidohydrolase

  Catalysed by ADSS2, ADSS1, NAT8L, ASPA and 1 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by ADSS2, ADSS1, SLC7A13, IDO1 and 2 moreinner side of the membrane, outer side of the membrane, cytosol

• oxalateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 4 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Citrate Transport, Mitochondrial

  Catalysed by ADSL, TNRC6B, FH, SLC25A1cytosol, mitochondrial matrixOne of 7 routes

• maleateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by ADSL, TNRC6B, SLC25A10cytosol, mitochondrial matrixOne of 4 routes

• orotateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. a quinone + succinate = fumarate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by ADSL, TNRC6B, SDHB, DHODHcytosol

• (S)-dihydroorotateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by ADSS2, ADSS1, CADcytosolOne of 2 routes

• isocitric acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by ADSL, TNRC6B, FH, SLC25A1cytosol, mitochondrial matrixOne of 3 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by ADSS2, ADSS1, GOT2mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC25A14 and 1 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-lysineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by ADSS2, ADSS1, SLC7A13, SLC7A7inner side of the membrane, outer side of the membraneOne of 4 routes

• cis-aconitic acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by ADSL, TNRC6B, FH, SLC25A1cytosol, mitochondrial matrixOne of 3 routes

• 3-oxopropanoateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ADSS2, ADSS1, GAD2, AGXT2cytosol

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by ADSS2, ADSS1, SLC7A13, IL4I1inner side of the membrane, outer side of the membrane, cytosol

• serotoninReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, SLC1A7, SLC1A3 and 4 moreextracellular space, cytosolOne of 2 routes

• D-cysteineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by ADSS2, ADSS1, AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)

  Catalysed by ADSS2, ADSS1, SLC7A13, SLC1A5inner side of the membrane, outer side of the membraneOne of 10 routes

• D-ribose 1-phosphateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. inosine:phosphate alpha-D-ribosyltransferase

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 3 morecytosol

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

  Catalysed by ADSS2, ADSS1, SLC7A13, TATinner side of the membrane, outer side of the membraneOne of 3 routes

• glyoxylateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by ADSL, TNRC6B, FH, CLYBLcytosol

• phosphoenolpyruvic acidReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by ADSS2, ADSS1, GOT2, PCK1mitochondrial matrix, cytosolOne of 2 routes

• L-ornithineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and ornithine (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, ASNS, SLC7A6cytosol, extracellular spaceOne of 24 routes

• gamma-Glu-AlaReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ADSS2, ADSS1, AGXT2, GGT1 and 5 moreextracellular space, cytosol

• taurineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ADSS2, ADSS1, NAT8L, BAATmitochondrial matrix, cytosolOne of 2 routes