octanoyl-CoA

Three steps

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by CROT, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by CROT, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CROT, NAGS, CARS2mitochondrial matrix

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by CROT, CPT1A, CPT1C, CPT1B and 7 moremitochondrial matrix, cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by CROT, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by CROT, HADHA, ACADVL, HADHBmitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by CROT, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  3. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by CROT, ECHS1, ACAA2, HADH and 1 moremitochondrial matrixOne of 3 routes

• docosanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. Docosanoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by CROT, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 2 routes

• octadecanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Stearoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosolOne of 4 routes

• alpha-linolenic acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CROT, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• phenylacetylglycineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by CROT, GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 6 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• CHEBI:28666Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. LTD4 hydrolysis

  Catalysed by CROT, ZDHHC11B, NAA10, ESCO2 and 29 moremitochondrial matrix, cytosolOne of 2 routes

• pyridoxine 5'-phosphateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CROT, SCLYmitochondrial matrix, cytosol

• N-acetyl-L-cysteineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CROT, NAGSmitochondrial matrix

• Cu(2+)Reach from here →
  1. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
  2. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by GLYATL2, PAM, CYBRD1inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
  2. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by GLYATL2, PAMOne of 10 routes

• K(+)Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by CROT, NAGS, SLC1A1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CROT, NAGS, CARS1mitochondrial matrix, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by CROT, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by CROT, NAGS, NARS1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Carnitine Transport by Atb0

  Catalysed by CROT, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 15 routes

• phosphocholineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by CROT, CHAT, PHOSPHO1mitochondrial matrix, nucleusOne of 2 routes

• glycocholateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. propanoyl-CoA C-acyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CROT, ACAA1, SCP2, MYO5B and 1 moremitochondrial matrix, peroxisomeOne of 5 routes

• cholateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. propanoyl-CoA C-acyltransferase
  3. choloyl-CoA hydrolase

  Catalysed by CROT, ACAA1, SCP2, MYO5B and 1 moremitochondrial matrix, peroxisome, cytosolOne of 2 routes

• hydrogen sulfideReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CROT, NAGS, CTHmitochondrial matrix, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by CROT, AGXT2mitochondrial matrixOne of 12 routes

• (9Z,12Z)-octadecadienoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosol

• 3-acetamidopropanalReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by CROT, PAOX, SMOXmitochondrial matrix, cytosolOne of 4 routes

• propionic acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Propanoate:CoA ligase (AMP-forming)
  3. Propanoyl-CoA hydrolase

  Catalysed by CROT, ACSS3, ACSS2, ACSS1 and 1 moremitochondrial matrix, cytosolOne of 3 routes

• citric acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. ATP citrate lyase (citrate)
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by CROT, ACLY, CSmitochondrial matrix, cytosolOne of 2 routes

• butyric acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Butanoate:CoA ligase (AMP-forming)
  3. Butyryl-CoA hydrolase

  Catalysed by CROT, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosol

• tetradecanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. Myristoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 10 moremitochondrial matrix, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CROT, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• adipic acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Activation of adipic acid for Formation of Adipoyl Carnitine
  3. Thioesterification of adipoyl-CoA for Release into Cytosol

  Catalysed by CROT, ACOT8mitochondrial matrix, cytosol, peroxisomeOne of 3 routes

• glutarateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Production of Glutaryl Carnitine
  3. glutaryl-CoA + H2O = glutarate + CoA + H(+)

  Catalysed by CROT, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosolOne of 7 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. ATP citrate lyase (citrate)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by CROT, ACLY, GOT2mitochondrial matrix, cytosol

• docosan-1-olReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• hexacosanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. Hexacosanoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• tetracosanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. Tetracosenoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• decanalReach from here →
  1. fatty acyl-CoA synthase (N-C10:0CoA)
  2. Decanoyl-CoA hydrolase
  3. decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)

  Catalysed by ACOT7, ALDH3A2cytosol

• an N-acylsphinganineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by CROT, ASAH1, ACER2, ACER1 and 7 moremitochondrial matrix, Golgi apparatus, cytosol

• octadecan-1-olReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• eicosanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. Eicosanoyl-CoA hydrolase

  Catalysed by CROT, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CROT, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 8 routes