an N-acylsphinganine

1. N-acylsphingosine amidohydrolase

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS2, SAMD8One of 2 routes

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid

Catalysed by ACER2, ACER1, ACER3

1. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

Catalysed by DEGS1, DEGS2cytosolOne of 2 routes

1. N-acylsphingosine amidohydrolase

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol

1. delta 4-desaturase, sphingolipid (dihydroceramide pool)

Catalysed by DEGS1, DEGS2cytosolOne of 5 routes

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid

Catalysed by ACER2, ACER1, ACER3

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS1, SGMS2

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS2, SAMD8

1. N-acylsphingosine amidohydrolase
2. sphingosine N-acyltransferase (sphinganine)

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 7 morecytosolOne of 2 routes

1. delta 4-desaturase, sphingolipid (dihydroceramide pool)
2. UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase

Catalysed by DEGS1, DEGS2, UGT8cytosolOne of 5 routes