malonic acid

Three steps

• 2-phenylethylamineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC6A14, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Glutamine by Atb0 Transporter
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC6A14, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC25A10, TSTD1, MGST3mitochondrial matrix, cytosol

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GPX1, GPX4mitochondrial matrix, cytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GPX1, GPX4mitochondrial matrix, cytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GPX1, GPX4mitochondrial matrix, cytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GPX1, GPX4mitochondrial matrix, cytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GPX4mitochondrial matrix, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, MPST, TST, AGXT2mitochondrial matrix, cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, MPST, TST, AGXT2mitochondrial matrix, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, MPST, TST, AGXT2mitochondrial matrix, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC6A9, SLC6A14, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC6A14, CARS2extracellular space, cytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SLC25A10, TSTD1, GSTP1mitochondrial matrix, cytosol

• a quinolReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A10, SDHB, SDHAmitochondrial matrix, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• phenylacetylglycineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC6A9, SLC6A14, GLYATextracellular space, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC6A14, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by SLC6A9, SLC6A14extracellular space, cytosol

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLC25A10, STSmitochondrial matrix, cytosolOne of 3 routes

• pyridoxine 5'-phosphateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC6A14, SCLYextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC6A14, NAGSextracellular space, cytosol, mitochondrial matrix

• L-ascorbic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SLC25A10, TSTD1, CLIC1, GSTO1 and 1 moremitochondrial matrix, cytosol

• K(+)Reach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC25A10, SLC25A14, SLC25A30, SLC1A7 and 4 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• Ca(2+)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC24A1, SLC24A5 and 3 moreextracellular space, cytosol

• Cys-tRNA(Cys)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC6A14, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC6A14, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC6A9, SLC6A14, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC25A10, SLC25A14, SLC25A30, DARS1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• Trp-tRNA(Trp)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC6A14, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC6A14, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC6A14, QARS1extracellular space, cytosol

• hypoioditeReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC26A4, MPO, LPOextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Asparagine by Atb0 Transporter
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC6A14, NARS1extracellular space, cytosol

• phosphocholineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLC25A10, TSTD1, ABCC4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• cholateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLC25A10, TSTD1, ABCC4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC25A10, SLC25A14, SLC25A30, SLC26A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• acetateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, MPST, TST, SLC16A4 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:30249Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC6A14, IDO1, TDO2, IDO2extracellular space, cytosol

• propionic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• citric acidReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 10 routes

• butyric acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• (9Z)-octadecenoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes