oxaloacetate

Three steps

• N-hexadecanoylglycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix

• N-dodecanoylglycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• N-decanoylglycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosolOne of 2 routes

• N-octanoylglycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by CS, CROT, GLYATL2mitochondrial matrixOne of 2 routes

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by CLYBL, PAMmitochondrial matrix, cytosol

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by CLYBL, PAMmitochondrial matrix, cytosol

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by CLYBL, PAMmitochondrial matrix, cytosol

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by CLYBL, PAMmitochondrial matrix, cytosol

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by CLYBL, PAMmitochondrial matrix, cytosol

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by CLYBL, PAMmitochondrial matrix, cytosol

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by GOT2, SLC7A13, DPEP1, DPEP2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-octadecanoyl-sphingoid baseReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• glycyldehydrophenylalanineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by GOT2, SLC7A13, PFASmitochondrial matrix, inner side of the membrane, outer side of the membrane

• kinetensinReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. Chymase

  Catalysed by GOT2, SLC7A13, CMA1mitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by CS, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol

• acetoneReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by FAHD1cytosol, mitochondrial matrix

• acetylcholineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by CS, CHATmitochondrial matrix, nucleus, cytosolOne of 3 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by GOT2, SLC7A13, PAHmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:15467Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by CS, AACS, HMGCS1mitochondrial matrix, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. transport of D-alanine and glutamine (cytosol to extracellular)

  Catalysed by GOT2, SLC7A13, SLC3A2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix, cytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by GOT2, SLC7A13, PAHmitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• CHEBI:15699Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and homoserine (cytosol to extracellular)

  Catalysed by GOT2, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 36 routes

• betaine aldehydeReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by CS, CHAT, CHDHmitochondrial matrix, nucleus, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by CS, SAT1, SAT2, DHPSmitochondrial matrix, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• CHEBI:15765Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. solute carrier (L-dopa)

  Catalysed by GOT2, SLC7A13, SLC3A2, SLC7A5mitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 1-acylglycerone 3-phosphateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 2 moremitochondrial matrix, Golgi apparatus, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by GOT2, SLC7A13, GFPT2, GFPT1mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• keto-D-fructose 6-phosphateReach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-fructose 6-phosphotransferase

  Catalysed by PCK1, PKM, PKLR, HK1 and 3 morecytosol

• N-acetyl-beta-D-glucosaminylamineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by GOT2, AGAmitochondrial matrix

• thioredoxin dithiolReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by GOT2, DARS1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and histidine (cytosol to extracellular)

  Catalysed by GOT2, ASNS, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 23 routes

• phosphatidylethanolamineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 6 moremitochondrial matrix, Golgi apparatus, cytosol

• 11-cis-retinalReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by CS, DGAT1, LRAT, AWAT1 and 9 moremitochondrial matrix, cytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatus, cytosol

• hexadecan-1-olReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol, peroxisome

• CHEBI:16174Reach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. dATP:pyruvate 2-O-phosphotransferase
  3. ATP:dADP phosphotransferase

  Catalysed by PCK1, PKM, PKLR, NME4 and 4 morecytosolOne of 23 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 10 moremitochondrial matrix, cytosolOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GOT2, AGXT2mitochondrial matrixOne of 3 routes

• phosphatidic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 10 moremitochondrial matrix, Golgi apparatusOne of 7 routes

• L-citrullineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

  Catalysed by GOT2, ASS1mitochondrial matrix, cytosolOne of 21 routes

• ubiquinonesReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. succinate:quinone oxidoreductase

  Catalysed by FH, SDHD, SDHB, SDHA and 1 moremitochondrial matrix, cytosol

• L-arginineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by GOT2, ASS1, ASLmitochondrial matrix, cytosolOne of 44 routes