pregnenolone sulfate

Three steps

• androsteroneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by STScytosolOne of 3 routes

• L-cystineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by STS, SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by STScytosolOne of 3 routes

• iodideReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular space

• ubiquinonesReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by STS, SLC25A10, SDHD, SDHB and 2 morecytosol, mitochondrial matrix

• L-valineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by STS, SLC25A10cytosol, mitochondrial matrixOne of 11 routes

• L-arginineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by STS, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membrane

• 3-fumarylpyruvateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by STS, SLC25A10, FAHD1cytosol, mitochondrial matrix

• CHEBI:16857Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• ferrocytochrome cReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by STS, SLC25A14, SLC25A30, SUOXcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 21-hydroxyprogesteroneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. Pregnenolone:NAD+ 3-oxidoreductase
  3. cytochrome P450 (progesterone)

  Catalysed by STS, HSD3B1, HSD3B2, CYP21A2cytosolOne of 3 routes

• L-isoleucineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular spaceOne of 3 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. cytochrome P450 (pregnenolone)
  3. 17alpha-Hydroxypregnenolone:NAD+ 3-oxidoreductase

  Catalysed by STS, CYP17A1, HSD3B1, HSD3B2cytosol, endoplasmic reticulumOne of 5 routes

• estroneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by STScytosolOne of 3 routes

• propanoateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• enol-oxaloacetateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by STScytosol, Golgi apparatusOne of 3 routes

• glycine betaineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 3 routes

• urateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• butanoateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• thiocyanateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 3 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by STS, SLC25A10, FAHcytosol, mitochondrial matrix

• L-glutamineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 3 routes

• CHEBI:18095Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by STS, SLC26A6cytosol, extracellular spaceOne of 2 routes

• hydrogen cyanideReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, MPST and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:240943Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by STS, SLC26A6, SLC6A5cytosol, extracellular spaceOne of 2 routes

• a quinolReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• hypochlorous acidReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by STS, SLC26A6, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 3 routes

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. cytochrome P450 (pregnenolone)
  3. cytochrome P450

  Catalysed by STS, CYP17A1, CYP21A2cytosol

• 11beta-hydroxyprogesteroneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. Pregnenolone:NAD+ 3-oxidoreductase
  3. progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

  Catalysed by STS, HSD3B1, HSD3B2, CYP11B1 and 1 morecytosolOne of 2 routes

• (20S)-hydroxypregn-4-en-3-oneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. Pregnenolone:NAD+ 3-oxidoreductase
  3. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)

  Catalysed by STS, HSD3B1, HSD3B2, AKR1C4 and 4 morecytosolOne of 2 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. cytochrome P450 (pregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by STS, CYP17A1cytosolOne of 9 routes

• 5alpha-pregnane-3,20-dioneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. Pregnenolone:NAD+ 3-oxidoreductase
  3. 5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase

  Catalysed by STS, HSD3B1, HSD3B2, SRD5A1 and 2 morecytosolOne of 2 routes

• K(+)Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC1A7 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by STS, SLC25A14, SLC25A30, DARS1cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. cytochrome P450 (pregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by STS, CYP17A1cytosolOne of 4 routes

• 5beta-pregnan-3,20-dioneReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. Pregnenolone:NAD+ 3-oxidoreductase
  3. progesterone + NADPH + H(+) = 5beta-pregnan-3,20-dione + NADP(+)

  Catalysed by STS, HSD3B1, HSD3B2, AKR1D1cytosol

• formic acidReach from here →
  1. Pregnenolone-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular spaceOne of 2 routes