(20S)-hydroxypregn-4-en-3-one

1. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)

Catalysed by AKR1C4, HSD17B2, AKR1C3, AKR1C2 and 1 more

1. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)
2. progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1C4, HSD17B2, AKR1C3, AKR1C2 and 3 more

1. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)
2. cytochrome P450 (progesterone)

Catalysed by AKR1C4, HSD17B2, AKR1C3, AKR1C2 and 2 morecytosolOne of 3 routes

1. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)
2. cytochrome P450 (progesterone)
3. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by AKR1C4, HSD17B2, AKR1C3, AKR1C2 and 2 morecytosol, endoplasmic reticulum

1. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)
2. cytochrome P450 (progesterone)
3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)