3-sulfino-L-alanine

Three steps

• CHEBI:16857Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and threonine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 34 routes

• ferrocytochrome cReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by GOT1, SUOXcytosol, mitochondrial matrix

• oxalic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular space

• (R)-3-hydroxybutyric acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by GOT1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• taurolithocholateReach from here →
  1. 3-sulfino-L-alanine carboxy-lyase
  2. Hypotaurine Oxidase, Extracellular
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by GAD1, CSAD, BAATcytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by GOT1, AGXTcytosol

• L-isoleucineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and isoleucine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 34 routes

• anilineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC25A12, SLC25A13, NAT8L, NAT2 and 1 moremitochondrial matrix, cytosol

• aceneuramateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by GOT1, NPLcytosol

• CHEBI:17312Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC25A12, SLC25A13, NAT8Lmitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by GOT1, TYW1B, TYW1cytosol

• D-aspartic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, SLC1A7, SLC1A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• CHEBI:17380Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC25A12, SLC25A13, SLC7A13, SLC7A5mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. Aspartate Intake by System Asct-1 Transporter
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC25A12, SLC25A13, PRODH2mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• AH2Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, CDKAL1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• L-cysteineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 50 routes

• indole-3-pyruvateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, IL4I1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Steryl-Sulfatase

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC25A12, SLC25A13, NAT8L, HADHA and 2 moremitochondrial matrix, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, AGXT2, AARS1mitochondrial matrix, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC25A12, SLC25A13, SLC7A13, TPH1 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A12, SLC25A13, SLC7A13, BCAT2mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:17895Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and tyrosine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 34 routes

• CHEBI:17927Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SLC25A12, SLC25A13, NAT8Lmitochondrial matrix, cytosol

• 3-oxopropanoic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A12, SLC25A13, GAD2, ABATmitochondrial matrix, cytosol

• 3-phenylpyruvateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC25A12, SLC25A13, SLC7A13, GOT2 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• fumaric acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by GOT1, SLC25A10cytosol, mitochondrial matrixOne of 10 routes

• CHEBI:18019Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and lysine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 18 routes

• dTDPReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. pyruvate kinase (dTDP)

  Catalysed by GOT1, PKM, PKLRcytosol

• CHEBI:18095Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. Aspartate Intake by System Asct-1 Transporter
  3. prolyl 4-hydroxylase (AKG)

  Catalysed by SLC25A12, SLC25A13, P4HA2, P4HB and 1 moremitochondrial matrix, cytosol, extracellular space, endoplasmic reticulumOne of 4 routes

• 2-phenylethylamineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, DDCmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• hydrogen cyanideReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by GOT1, MPST, TSTcytosol, mitochondrial matrixOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, PFASmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• S-methylmercury-L-cysteineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, SLC7A8mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC25A12, SLC25A13, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GOT1, AGXT2cytosolOne of 8 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A12, SLC25A13, AGXT2mitochondrial matrix, cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GOT1, AGXT2cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GOT1, AGXT2cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC25A12, SLC25A13, NAT8L, HADHA and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC25A12, SLC25A13, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC25A12, SLC25A13, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC25A12, SLC25A13, NAT8L, HADHA and 2 moremitochondrial matrix, cytosolOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC25A12, SLC25A13, NAT8L, HADHA and 2 moremitochondrial matrix, cytosol

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC25A12, SLC25A13, NAT8L, ECHS1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC25A12, SLC25A13, NAT8L, ECHS1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• folic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Folate Transport by Oats

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• CHEBI:27540Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC25A12, SLC25A13, NAT8L, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC25A12, SLC25A13, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, TPH1 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes