S-sulfanylglutathione

Three steps

• xanthineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by ETHE1, SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17724Reach from here →
  1. Persulfide dioxygenase
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by ETHE1, BHMT, BHMT2mitochondrial matrix, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DDCmitochondrial matrix, extracellular space, cytosol

• prostaglandin F1Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by ETHE1, SLCO2A1, DHRS1mitochondrial matrix, extracellular space, cytosol

• CHEBI:17895Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:18019Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Persulfide dioxygenase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by ETHE1, SLC25A10, FAHmitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by ETHE1, SLC3A2, SLC7A5, SLC7A10mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• 5-hydroxyisourateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate:oxygen oxidoreductase

  Catalysed by ETHE1, SLC22A13inner side of the membrane, outer side of the membrane, cytosol

• dTDPReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate kinase (dTDP)

  Catalysed by ETHE1, MPST, TST, PKM and 1 moremitochondrial matrix, cytosol

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, MAOA and 1 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:18183Reach from here →
  1. Persulfide dioxygenase
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by ETHE1, GGT1, GGT5, GGTLC2 and 5 moremitochondrial matrix, extracellular space, cytosol

• (R)-normetanephrineReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, COMT and 1 moremitochondrial matrix, extracellular space, cytosol

• glycodeoxycholate 3-sulfateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Persulfide dioxygenase
  2. Formation of Homocystine
  3. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase

  Catalysed by ETHE1, MTRmitochondrial matrix, cytosol

• S-disulfanyl-L-cysteineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by ETHE1, CARS2mitochondrial matrix, cytosol

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by ETHE1, UGT1A9, UGT2B7, UGT1A6 and 3 moremitochondrial matrix, extracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by ETHE1, SLCO2A1, UGT2B7, UGT1A1 and 1 moremitochondrial matrix, extracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by ETHE1, SLCO2A1, UGT1A9, UGT2B7 and 2 moremitochondrial matrix, extracellular space, cytosol

• serotonin O-sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moremitochondrial matrix, extracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT1A3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-homocysteine thiolactoneReach from here →
  1. Persulfide dioxygenase
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by ETHE1, PON1, PON2, PON3mitochondrial matrix, cytosol

• ursodeoxycholate 3-sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT2A1mitochondrial matrix, extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT2A1mitochondrial matrix, extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT2A1mitochondrial matrix, extracellular space, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• deoxycholateReach from here →
  1. Persulfide dioxygenase
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, CYP7A1mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• dimethylarsinous acidReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ETHE1, AS3MT

• potassium atomReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLC6A4mitochondrial matrix, extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by ETHE1, FAAHmitochondrial matrix, extracellular space, cytosol

• trimethylarsineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by ETHE1, AS3MT

• imidazole-4-acetaldehydeReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and histamine (cytosol to extracellular)
  3. amine oxidase copper containing (histamine)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, AOC2 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• folic acidReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Folate Transport by Oats

  Catalysed by ETHE1, SUOX, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 3,4-dihydroxyphenylacetaldehydeReach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. monoamine oxidase (dopamine)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, AOC2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:28918Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, PNMTmitochondrial matrix, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ETHE1, NAGSmitochondrial matrix, cytosol

• a dicarboxylateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLC22A6mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• iron(2+)Reach from here →
  1. Persulfide dioxygenase
  2. glutathione:dehydroascorbate oxidoreductase
  3. cytochrome b reductase (ascorbate)

  Catalysed by ETHE1, CYBRD1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• K(+)Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLC6A4mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• Cys-tRNA(Cys)Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by ETHE1, CARS1mitochondrial matrix, cytosol

• a thiolReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by ETHE1, TSTD1, SUMF1

• chlorine(.)Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by ETHE1, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 5 routes

• D-aspartateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. Persulfide dioxygenase
  2. transport of acetylcholine and GSH (cytosol to extracellular)
  3. Acetylcholine aectylhydrolase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, BCHE and 1 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• oxalateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC26A2 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. Persulfide dioxygenase
  2. alcohol dehydrogenase (formaldehyde)
  3. S-Formylglutathione hydrolase

  Catalysed by ETHE1, ADH1C, ADH1A, ADH5 and 4 moremitochondrial matrix, cytosolOne of 3 routes