Compound

3,4-dihydroxyphenylacetaldehyde

A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.

Definition from ChEBI (CHEBI:27978), read 2026-09-23. CC BY 4.0.

CHEBI:27978ChEBI

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Structure

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A generated conformer of 3,4-dihydroxyphenylacetaldehyde — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C8H8O3
Mass: 152.149 g/mol
Charge: 0
InChIKey: IADQVXRMSNIUEL-UHFFFAOYSA-N
SMILES: [H]C(=O)Cc1ccc(O)c(O)c1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

7 entities

7 entities reached.

0 reported hops7 assembled from the scaffold

What the reference databases state

Statements

19 statements

19 statements · 2 reference databases · Subject: 3,4-dihydroxyphenylacetaldehyde · Sources: Human-GEM, Rhea

Order

3,4-dihydroxyphenylacetate is converted to 3,4-dihydroxyphenylacetaldehydeCompoundRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundHuman-GEM MAR06760Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundHuman-GEM MAR06761Inferred only
dopamine is converted to 3,4-dihydroxyphenylacetaldehydeCompoundHuman-GEM MAR06758Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to dopamineCompoundRhea RHEA:27946Inferred only
dopamine is converted to 3,4-dihydroxyphenylacetaldehydeCompoundRhea RHEA:27946Inferred only
L-dopa is converted to 3,4-dihydroxyphenylacetaldehydeCompoundRhea RHEA:55524Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to L-dopaCompoundRhea RHEA:55524Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH3A1ProteinHuman-GEM MAR06761Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH3A1ProteinHuman-GEM MAR06760Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH3B1ProteinHuman-GEM MAR06761Inferred only

Show the remaining 7

3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH3B1ProteinHuman-GEM MAR06760Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH3B2ProteinHuman-GEM MAR06761Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH3B2ProteinHuman-GEM MAR06760Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by ALDH9A1ProteinRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by MAOAProteinRhea RHEA:27946Inferred only
3,4-dihydroxyphenylacetaldehyde is metabolised by MAOBProteinRhea RHEA:27946Inferred only
3,4-dihydroxyphenylacetaldehyde is a substrate of AKR1A1ProteinHuman-GEM MAR12005Inferred only

Reactions

8 reactions

dopamine+water+dioxygen3,4-dihydroxyphenylacetaldehyde+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06758CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+dopaminewater+MAM02621c
Reaction pageReversibleBalancedEC 3.5.99.14cytosol
Human-GEM MAR06759CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+water+NAD(+)3,4-dihydroxyphenylacetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06760CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+water+NADP(3-)3,4-dihydroxyphenylacetate+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06761CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+proton+NADPH(4-)NADP(3-)+MAM03197c
Catalysed by AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.2cytosol
Human-GEM MAR12005CC BY 4.0Reference data
dopamine+dioxygen+water3,4-dihydroxyphenylacetaldehyde+hydrogen peroxide+ammonium
Catalysed by MAOA or MAOB
Reaction pageDirection not assertedBalanced
Rhea RHEA:27946CC BY 4.0Reference data
L-dopa+dioxygen+water+hydron3,4-dihydroxyphenylacetaldehyde+hydrogen peroxide+ammonium+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:55524CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+NAD(1-)+water3,4-dihydroxyphenylacetate+NADH(2-)+2hydron
Catalysed by ALDH9A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:69080CC BY 4.0Reference data

Other names

4 names

Resolves to: 3,4-dihydroxyphenylacetaldehyde

Also called: 2-(3,4-dihydroxyphenyl)ethanalDOPALProtocatechuatealdehyde
Systematic name: (3,4-dihydroxyphenyl)acetaldehyde