N(1),N(12)-diacetylspermine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

159 compounds within 3 steps: 4 in 1, 6 in 2, 149 in 3

Three steps

CHEBI:17769Reach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. spermidine:(acceptor) oxidoreductase
Catalysed by PAOX, SMOXcytosolOne of 3 routes
CHEBI:17895Reach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. transport of arginine and tyrosine (cytosol to extracellular)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6cytosol, extracellular spaceOne of 2 routes
CHEBI:18019Reach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. transport of arginine and lysine (cytosol to extracellular)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular spaceOne of 4 routes
L-glutamineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. transport of arginine and glutamine (cytosol to extracellular)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6cytosol, extracellular spaceOne of 5 routes
spermine monoaldehydeReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. diamine N-acetyltransferase (N1-acetylspermine)
3. primary-amine oxidase (spermine)
Catalysed by SAT1, SAT2, AOC2, AOC1 and 1 morecytosolOne of 3 routes
N-(4-aminobutyl)-3-aminopropanalReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. primary-amine oxidase (spermidine)
Catalysed by PAOX, SMOX, AOC2, AOC1 and 1 morecytosolOne of 3 routes
(5Z)-dodecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)
Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 2 routes
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
(7Z)-tetradecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes
(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
Catalysed by HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 3 routes
(7Z,10Z)-hexadecadienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
Catalysed by HADHA, ACADVL, HADHBcytosol, mitochondrial matrix
(4Z,7Z)-decadienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
Catalysed by ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes
(5Z)-octenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial
Catalysed by ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes
CHEBI:27540Reach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. medium-chain acyl-CoA ligase (hexanoic acid)
Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 6 routes
elaidic acidReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (elaidate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
CHEBI:28701Reach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Propanoyl-CoA:acetyl-CoA C-acyltransferase
Catalysed by ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes
chlorine(.)Reach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. transport of arginine and chloride (cytosol to extracellular)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular spaceOne of 2 routes
L-lysineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membrane
spermineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+)
Catalysed by PAOX, SMOX, SMScytosolOne of 2 routes
L-ornithineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. L-ornithine + H(+) = putrescine + CO2
Catalysed by PAOX, SMOX, ODC1cytosolOne of 15 routes
taurineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
Catalysed by BAATcytosolOne of 2 routes
glycineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. glycine N-acyltransferase (N-arachidonoylglycine)
Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 12 routes
(R)-methylmalonyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
Catalysed by ALDH6A1cytosol, mitochondrial matrixOne of 2 routes
(S)-methylmalonyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. (S)-methylmalonyl-CoA hydrolase
No catalyst recordedcytosol, mitochondrial matrix
3'-dephospho-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. acid phosphatase 2, lysosomal (CoA)
Catalysed by ACP2cytosol, lysosomeOne of 2 routes
(2E)-dodecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. (2E)-dodecenoyl-CoA formation
No catalyst recordedcytosol, mitochondrial matrixOne of 3 routes
4,8,12-trimethyltridecanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)
Catalysed by ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes
butanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Butanoate:CoA ligase (AMP-forming)
Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 9 routes
dodecanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (lauric acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes
glutaryl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Production of Glutaryl Carnitine
Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes
eicosanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (eicosanoate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 12 routes
itaconyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Itaconate:CoA ligase (GDP-forming)
Catalysed by SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 13 routes
tetradecanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (myristic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 11 routes
octanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Octanoyl-CoA:L-carnitine O-octanoyltransferase
Catalysed by CROTcytosol, mitochondrial matrixOne of 20 routes
phytanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. phytanate-CoA ligase
No catalyst recordedcytosolOne of 5 routes
octadecanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 3 morecytosolOne of 15 routes
S-adenosyl 3-(methylsulfanyl)propylamineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
Catalysed by PAOX, SMOX, SRMcytosol
2-(N(omega)-L-arginino)succinateReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular spaceOne of 2 routes
propane-1,3-diamineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
Catalysed by PAOX, SMOX, DHPScytosol
4-guanidinobutanoateReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular space
3-guanidinopropanoateReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular space
L-histidineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 3 routes
guanidinoacetateReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. L-Arginine:glycine amidinotransferase
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular spaceOne of 2 routes
sphing-4-enineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 2 routes
L-methionineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. N-acetylglutamate synthase (N-acetylmethionine)
Catalysed by NAGScytosol, mitochondrial matrixOne of 6 routes
L-tryptophanReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. transport of arginine and tryptophan (cytosol to extracellular)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6cytosol, extracellular spaceOne of 2 routes
L-alanineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
No catalyst recordedcytosol, mitochondrial matrixOne of 4 routes
L-asparagineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. N-acetylglutamate synthase (N-acetyl-L-asparagine)
Catalysed by NAGScytosol, mitochondrial matrixOne of 3 routes