leukotriene C4

Two steps

• glycolithocholic acidReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GCATcytosol, mitochondrial matrix

• tert-butanolReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 5 more

• L-ornithineReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GATMcytosolOne of 5 routes

• gamma-Glu-AlaReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO1B1, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. leukotriene C4 hydrolysis
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLDC, GCSHcytosol, mitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• prostaglandin E1Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. leukotriene C4 hydrolysis
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. leukotriene C4 hydrolysis
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SHMT1, SHMT2cytosol

• leukotriene E4Reach from here →
  1. leukotriene C4 + H2O = leukotriene D4 + L-glutamate
  2. leukotriene D4 + H2O = leukotriene E4 + glycine

  Catalysed by GGT1, GGT5, DPEP1, DPEP2

• (R)-S-lactoylglutathioneReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO1B1, GLO1, GLOD4extracellular space, cytosolOne of 3 routes

• an N-acylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL3, GLYAT, GLYATL2cytosol

• S-formylglutathioneReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1B1, ADH1C, ADH1A, ADH5 and 3 moreextracellular space, cytosolOne of 2 routes

• guanidinoacetateReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 5 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• L-tryptophanReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 5 routes

• L-alanineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 6 routes

• L-asparagineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of asparagine and glycine (cytosol to extracellular)

  No catalyst recordedcytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 7 routes

• glutathione disulfideReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 35 routes

• taurolithocholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-tyrosineReach from here →
  1. leukotriene C4 hydrolysis
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by AADATcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. leukotriene C4 hydrolysis
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT2cytosol

• 5-oxo-L-prolineReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• histamineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO1B1, SQORextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. leukotriene C4 hydrolysis
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by GLYATL2cytosolOne of 2 routes

• dopamineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• N-benzoylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. Hippurate (Benzoylglycinate) Formation

  No catalyst recordedcytosol, mitochondrial matrixOne of 2 routes

• L-cysteinylglycineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO1B1, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 more

• (R)-noradrenalineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (2S)-2-aminobutanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by AGXT2cytosol

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• ursodeoxycholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• glycodeoxycholateReach from here →
  1. leukotriene C4 hydrolysis
  2. Glycodeoxycholate amidohydrolase

  No catalyst recordedcytosolOne of 3 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 more