L-dopa

Three steps

• glycolithocholic acidReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC7A8, SLC7A5, GCATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• (6R)-L-erythro-6,7-dihydrobiopterinReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by SLC7A8, PAH, PCBD1, PCBD2inner side of the membrane, outer side of the membrane

• gamma-Glu-AlaReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by DDC, SLCO1A2, SLCO1B3, GGT1 and 5 moreextracellular space, cytosolOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC7A8, SLC7A5, GLDC, GCSHinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC7A8, SLC6A14, SLC6A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• prostaglandin E1Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosol

• D-alanineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC7A8, SLC7A5, PIPOXinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC7A8, SLC7A5, SHMT1, SHMT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• leukotriene A4Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC7A8, SLC7A6, ASLinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• (R)-S-lactoylglutathioneReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by DDC, SLCO1A2, SLCO1B3, GLO1 and 1 moreextracellular space, cytosolOne of 2 routes

• carnosineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by SLC7A8, CARNS1inner side of the membrane, outer side of the membrane

• 4-guanidinobutanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by SLC7A8, SLC7A6, GATMinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by SLC7A8, SLC7A13, ADSS2, ADSS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by SLC7A8, SLC7A6, GATMinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-ornithineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, GLYATL3, GLYAT and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A5, GOT2, GOT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by DDC, SLCO1A2, SLCO1B3, ADH1C and 5 moreextracellular space, cytosol

• guanidinoacetateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SLC7A8, SLC7A5, GATMinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• D-threonineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• glutathioneReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by SLC7A8, SLC7A5, GSSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-threonineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

• L-saccharopineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by SLC7A8, SLC7A6, AASSinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• beta-alanineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• leukotriene C4Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 7 routes

• taurocyamineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by SLC7A8, SLC7A6, GATMinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-glutamate 5-semialdehydeReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by SLC7A8, SLC7A6, OATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC7A8, SLC7A13, AGAinner side of the membrane, outer side of the membrane

• 3-hydroxy-L-kynurenineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by SLC7A8, SLC7A5, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A5, GCLC, GCLMinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by SLC7A8, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisome

• L-homocysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A8, SLC7A5, BHMT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• carbamoyl phosphateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

  Catalysed by SLC7A8, SLC7A5, CADinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A8, SLC7A5, BHMT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glutathione disulfideReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 14 routes

• taurolithocholate 3-sulfateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 7 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC7A8, SLC7A5, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• histamineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

• L-2-aminopentanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Kynurenine
  3. 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

  Catalysed by SLC7A8, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol