3,3',5-triiodo-L-thyronine

Three steps

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. De novo synthesis of 2Fe2S

  Catalysed by SLCO1A2, SLCO1B3, NDUFAB1, FDXR and 5 moreextracellular space, cytosol, mitochondrial matrix

• fatty acidReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• CHEBI:37946Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. aryl sulfotransferase (dopamine)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 2 moreextracellular space, cytosol

• (R)-lactic acidReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-Lactoylglutathione hydrolase

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 2 moreextracellular space, cytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin A2 (cytosol to extracellular)
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• 25-hydroxycholesterolReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1 and 1 more

• all-trans-4-oxoretinolReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. cytochrome P450 (retinol)

  Catalysed by DIO1, DIO3, RETSAT, CYP26A1cytosol

• phosphoenolpyruvic acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by DIO1, DIO3, D2HGDH, PCK1cytosolOne of 2 routes

• 13-cis-retinolReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol binding protein (retinol)

  Catalysed by DIO1, DIO3, RETSAT, RBP1 and 1 morecytosolOne of 2 routes

• L-ornithineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• N-methylserotoninReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, INMTextracellular space, cytosol

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by SLCO1A2, SLCO1B3, MAOA, MAOBextracellular space, cytosolOne of 2 routes

• taurineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by DIO1, DIO3, DIO2, SLC26A4 and 1 morecytosol, extracellular spaceOne of 2 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by SLCO1A2, SLCO1B3, FAAHextracellular space, cytosol

• malonaldehydeReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, TBXAS1extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 hydrolysis

  Catalysed by SLCO1A2, SLCO1B3, LTC4Sextracellular space, cytosolOne of 14 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by SLCO1A2, SLCO1B3, SLC27A2, ACSL4 and 9 moreextracellular space, cytosol

• choloyl-CoAReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosol

• 15-oxoprostaglandin E2Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by SLCO1A2, SLCO1B3, HPGDextracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin E1Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, CBR3 and 2 moreextracellular space, cytosolOne of 3 routes

• 15-oxoprostaglandin D2Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. Glutathione: 15-HPETE oxidoreductase
  3. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 3 routes

• sarcosineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by DIO1, DIO3, KDM1A, KDM1B and 1 more

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLCO1A2, SLCO1B3, ALOX5, ALOX15 and 1 moreextracellular space, cytosol

• thromboxane A2Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. thromboxane A2 hydrolysis

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by SLCO1A2, SLCO1B3, ALOX15B, ALOX15 and 1 moreextracellular space, cytosol

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by SLCO1A2, SLCO1B3, ALOX5extracellular space, cytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

  Catalysed by DIO1, DIO3, MTO1, DHFR and 1 more

• L-dopaReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• 3,5-diiodo-L-tyrosineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. iodide:hydrogen-peroxide oxidoreductase
  3. thyroid peroxidase (3-iodo-L-tyrosine)

  Catalysed by DIO1, DIO3, DIO2, TPOcytosolOne of 2 routes

• L-histidineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. L-histidine + H(+) = histamine + CO2

  Catalysed by SLCO1A2, SLCO1B3, HDCextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by SLCO1A2, SLCO1B3, GOT2, GOT1extracellular space, cytosolOne of 3 routes

• guanidinoacetateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by DIO1, DIO3, DIO2, SLC26A4cytosol, extracellular space

• L-methionineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 14 routes

• N-sulfo-D-glucosamineReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 2 morecytosol

• L-tryptophanReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 6 routes

• glutathioneReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 8 moreextracellular space, cytosolOne of 16 routes

• beta-alanineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLC26A4 and 2 morecytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. glutathione gamma-glutamylaminopeptidase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO1A2, SLCO1B3, GGTLC3, GGT1 and 4 moreextracellular space, cytosolOne of 21 routes

• L-asparagineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 6 routes

• L-phenylalanineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 8 routes

• L,L-cystathionineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. Formation of Homocystine
  3. L-serine hydro-lyase (adding homocysteine

  Catalysed by SLCO1A2, SLCO1B3, CBSextracellular space, cytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by SLCO1A2, SLCO1B3, GCLC, GCLMextracellular space, cytosolOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosolOne of 4 routes

• S-sulfanyl-L-cysteineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLCO1A2, SLCO1B3, CARS2extracellular space, cytosol

• N(tau)-methylhistamineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, HNMTextracellular space, cytosolOne of 3 routes

• phosphoenolpyruvateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by DIO1, DIO3, D2HGDH, PCK1 and 1 more

• hyodeoxycholateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by SLCO1A2, SLCO1B3, FAAH, PM20D1extracellular space, cytosol