Compound
a 3-oxoacyl-CoA
An acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate OH groups of any 3-oxoacyl-CoA; major species at pH 7.3.
Definition from ChEBI (CHEBI:90726), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound, anion
- Formula
- C24H33N7O18P3SR
- Mass
- 832.543 g/mol
- Charge
- -4
- SMILES
- *C(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- HSD17B10ProteinUNIPROT:Q99714substrate ofInferred only33 paths33 endpoints
- HADHBProteinUNIPROT:P55084substrate ofInferred only33 paths32 endpoints
- ACAA1ProteinUNIPROT:P09110substrate ofInferred only24 paths24 endpoints
- HADHProteinUNIPROT:Q16836substrate ofInferred only22 paths22 endpoints
- EHHADHProteinUNIPROT:Q08426substrate ofInferred only21 paths21 endpoints
- SCP2ProteinUNIPROT:P22307substrate ofInferred only21 paths21 endpoints
- ACAA2ProteinUNIPROT:P42765substrate ofInferred only10 paths10 endpoints
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: a 3-oxoacyl-CoA · Sources: Rhea
- a (3R)-3-hydroxyacyl-CoA is converted to a 3-oxoacyl-CoACompoundRhea RHEA:22256Inferred only
- a (3R)-3-hydroxyacyl-CoA is converted to a 3-oxoacyl-CoACompoundRhea RHEA:32711Inferred only
- a 3-oxoacyl-CoA is converted to a (3R)-3-hydroxyacyl-CoACompoundRhea RHEA:22256Inferred only
- a (3S)-3-hydroxyacyl-CoA is converted to a 3-oxoacyl-CoACompoundRhea RHEA:22432Inferred only
- a 3-oxoacyl-CoA is converted to a (3S)-3-hydroxyacyl-CoACompoundRhea RHEA:22432Inferred only
- an acyl-CoA is converted to a 3-oxoacyl-CoACompoundRhea RHEA:50252Inferred only
- a 3-oxoacyl-CoA is converted to an acyl-CoACompoundRhea RHEA:21564Inferred only
- a 3-oxoacyl-CoA is converted to an acyl-CoACompoundRhea RHEA:50252Inferred only
- an acyl-CoA is converted to a 3-oxoacyl-CoACompoundRhea RHEA:21564Inferred only
- a 3-oxoacyl-CoA is a substrate of ACAA1ProteinRhea RHEA:21564Inferred only
- a 3-oxoacyl-CoA is a substrate of ACAA2ProteinRhea RHEA:21564Inferred only
- a 3-oxoacyl-CoA is a substrate of EHHADHProteinRhea RHEA:22432Inferred only
Show the remaining 4
- a 3-oxoacyl-CoA is a substrate of HADHProteinRhea RHEA:22432Inferred only
- a 3-oxoacyl-CoA is a substrate of HADHBProteinRhea RHEA:21564Inferred only
- a 3-oxoacyl-CoA is a substrate of HSD17B10ProteinRhea RHEA:22432Inferred only
- a 3-oxoacyl-CoA is a substrate of SCP2ProteinRhea RHEA:21564Inferred only
Reactions
6 reactions
an acyl-CoA+acetyl-CoAa 3-oxoacyl-CoA+coenzyme A(4-)
Catalysed by ACAA1 or SCP2 or ACAA2 or HADHB
Reaction pageReversibleBalance undeterminable
Rhea RHEA:21564CC BY 4.0Reference data
a (3R)-3-hydroxyacyl-CoA+NADP(3-)a 3-oxoacyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22256CC BY 4.0Reference data
a (3S)-3-hydroxyacyl-CoA+NAD(1-)a 3-oxoacyl-CoA+NADH(2-)+hydron
Catalysed by EHHADH or HADH or HSD17B10
Reaction pageReversibleBalance undeterminable
Rhea RHEA:22432CC BY 4.0Reference data
a 3-oxo acid+succinyl-CoAa 3-oxoacyl-CoA+succinate(2-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24564CC BY 4.0Reference data
a (3R)-3-hydroxyacyl-CoA+NAD(1-)a 3-oxoacyl-CoA+NADH(2-)+hydron
Catalysed by HSD17B4 or HSD17B8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32711CC BY 4.0Reference data
an acyl-CoA+malonyl-CoA+hydrona 3-oxoacyl-CoA+carbon dioxide+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50252CC BY 4.0Reference data
Other names
1 name
Resolves to: a 3-oxoacyl-CoA
- Also called
- 3-oxoacyl-CoA(4-)