cholate

Three steps

• CHEBI:15477Reach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC27A2, SLC27A5, BAAT, GLYAT and 2 moreendoplasmic reticulum, peroxisome, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 1 moreendoplasmic reticulum, peroxisome, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SLC27A2, SLC27A5, BAAT, HADHA and 2 moreendoplasmic reticulum, peroxisome, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SLC27A2, SLC27A5, BAAT, GLYATendoplasmic reticulum, peroxisome, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SLC27A2, SLC27A5, BAAT, GLYAT and 2 moreendoplasmic reticulum, peroxisome, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 moreendoplasmic reticulum, peroxisome, cytosolOne of 14 routes

• palmitoyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 moreendoplasmic reticulum, peroxisome, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 moreendoplasmic reticulum, peroxisome, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by SLC27A2, SLC27A5, BAATendoplasmic reticulum, peroxisome, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSS3 and 2 moreendoplasmic reticulum, peroxisome, cytosolOne of 43 routes

• (S)-malateReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by ABCC4, TSTD1, SLC25A10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• L-leucineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and leucine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A9, SLC3A1extracellular space, cytosolOne of 3 routes

• 12(S)-HPETEReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, ALOX12extracellular space, cytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. Glutathione: 5-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 7 routes

• 5(S)-HPETEReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, ALOX5extracellular space, cytosol

• CHEBI:15699Reach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• CHEBI:15727Reach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SLC27A2, SLC27A5, BAAT, NAA10endoplasmic reticulum, peroxisome, cytosol

• formateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 5 moreextracellular space, cytosol

• CHEBI:15746Reach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC27A2, SLC27A5, BAAT, SAT1 and 1 moreendoplasmic reticulum, peroxisome, cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• (R)-lactateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 1 moreextracellular space, cytosol

• methanethiolReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by ABCC4, TSTD1, SELENBP1inner side of the membrane, outer side of the membrane

• octan-1-olReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• sulfateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by SLCO1A2, SLCO1B3, STSextracellular space, cytosolOne of 13 routes

• ureaReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by ABCC4, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• dimethylarsinateReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ABCC4, GSTO1, GSTO2, HEMK2inner side of the membrane, outer side of the membrane

• L-cystineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 5 routes

• 11-cis-retinolReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC27A2, SLC27A5, BAAT, DGAT1 and 4 moreendoplasmic reticulum, peroxisome, cytosol

• L-citrullineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• iodideReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2extracellular space, cytosolOne of 9 routes

• L-valineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACLYendoplasmic reticulum, peroxisome, cytosol

• L-arginineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 5 routes

• protein polypeptide chainReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. PROTEIN_BS

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

• (S)-lactateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 15 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (GSH)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A9, SULT2A1extracellular space, cytosol

• dopamine quinoneReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• formaldehydeReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 4 moreextracellular space, cytosol

• CHEBI:16857Reach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• ferrocytochrome cReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by ABCC4, TSTD1, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• (R)-lactaldehydeReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 7 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• dehydroascorbic acidReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• anilineReach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC27A2, SLC27A5, BAAT, NAT2 and 1 moreendoplasmic reticulum, peroxisome, cytosol

• CHEBI:17312Reach from here →
  1. Cholate:CoA ligase (AMP-forming)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC27A2, SLC27A5, BAATendoplasmic reticulum, peroxisome, cytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 2 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 1 moreextracellular space, cytosol