CHEBI:27760

Three steps

• 2-iminopropanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by CTH, AGXT2, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. pyruvate kinase (dTDP)

  Catalysed by CTH, AGXT2, PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by CTH, AGXT2, NPLcytosol

• L-ornithineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and ornithine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A6cytosol, extracellular spaceOne of 3 routes

• gamma-Glu-AlaReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by CTH, SCLY, GGT1, GGT5 and 4 morecytosol, extracellular space

• a 3-acylpyruvateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by CTH, AGXT2, FAHD1cytosol

• glycineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. L-threonine = acetaldehyde + glycine

  Catalysed by CTH, SDS, SDSL, SHMT1cytosolOne of 29 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutyrate oxidation
  3. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)

  Catalysed by CTH, PCCA, PCCBcytosol, mitochondrial matrix

• acryloyl-CoAReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutyrate oxidation
  3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)

  Catalysed by CTH, ACADS, ACADSBcytosol, mitochondrial matrix

• D-alanineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by CTH, SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. L-Serine hydro-lyase (adding homocysteine)
  2. Methionine Synthase
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by CBS, DHFR, DHFR2cytosol, nucleusOne of 3 routes

• 5-formimidoyltetrahydrofolateReach from here →
  1. L-Serine hydro-lyase (adding homocysteine)
  2. Methionine Synthase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by CBS, FTCDcytosol, nucleus

• 2-oxoadipateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by CTH, AGXT2, MPSTcytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by CTH, AGXT2cytosol

• D-threonineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by CTH, SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CTH, AGXT2, TYW1B, TYW1cytosolOne of 8 routes

• L-tryptophanReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and tryptophan (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 4 routes

• L-kynurenineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by CTH, SCLY, KYNUcytosol

• beta-alanineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by CTH, SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-asparagineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and asparagine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 6 routes

• L-phenylalanineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by CTH, SCLY, SLC7A5cytosol, extracellular spaceOne of 6 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by CTH, SCLY, KYNUcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
  3. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate

  Catalysed by CTH, AADAT, AGXT2cytosolOne of 8 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)

  Catalysed by CTH, SDS, SDSL, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. L-Serine hydro-lyase (adding homocysteine)
  2. Methionine Synthase
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by CBS, ATICcytosol, nucleus

• (3S)-citramalyl-CoAReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by CTH, AGXT2, CLYBLcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine

  Catalysed by CTH, AGXT2cytosolOne of 2 routes

• L-prolineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by CTH, SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by CTH, SCLY, GGTLC3, GGT1 and 4 morecytosolOne of 2 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CTH, AGXT2, HOGA1cytosolOne of 2 routes

• xanthurenateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by CTH, AGXT2, KYAT3, AADATcytosol

• Mo-molybdopterinReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CTH, SCLY, MOCOScytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CTH, AGXT2, HOGA1cytosolOne of 2 routes

• L-threonylcarbamoyladenylateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by CTH, SDS, SDSL, YRDCcytosol

• 3-methylmalateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by CTH, AGXT2, CLYBLcytosol

• thiamine(1+) diphosphateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)
  3. lipoamide to thiamin-PP conversion

  Catalysed by CTH, BCKDHA, BCKDHB, DBTcytosol, mitochondrial matrix

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. Selenocystathionine Lysteine-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by CTH, AGXT2, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix